Variation in Longevity Gene KLOTHO Associates with Measures of Resilience Against Parkinson’s Disease
Objective: We investigated whether carrying one copy of the protective haplotype “KL-VS” of the longevity gene KLOTHO is associated with better cognitive functioning and/or attenuated…Disease-modification in Translational Models of Parkinson’s disease by the Rho Kinase Inhibitor Fasudil
Objective: To evaluate the therapeutic potential of the Rho Kinase (ROCK) inhibitor Fasudil in translational models of Parkinson’s disease (PD). Background: There is still a…a-synuclein neurotoxicity and spreading using Lewy Body extracts from Parkinson Disease Brains: In vitro screening by cell-based assays
Objective: To define the kinetics of neuronal and astrocytic abnormalities induced by human-derived α-syn aggregates for grounding the use of such system to identify and…SNCA multiplication consortium: Clinicogenetic analysis of SNCA multiplication probands and families.
Objective: Clinicogenetic analysis of 57 affected probands with SNCA multiplication, 3 unaffected carriers, and their 60 families. To use informative pedigrees to identify penetrance modifiers…The novel Parkinson´s disease locus RIT2 and alpha-synuclein function in intersecting pathways
Objective: We aim to describe the molecular pathways at the crossroad of etiology and susceptibility in PD, focusing on Rin, coded by the recently associated…Assessment of neurodegeneration and spreading of α-synuclein pathology induced by structurally defined α-synuclein assemblies in wild-type mice
Objective: The aim of this study was to investigate, in wild-type mice, the spreading and neurodegeneration induced by intracerebral injection of structurally well-defined α-synuclein assemblies…Physical and cognitive stimulation through environmental enrichment prevents early molecular pathology in a Parkinson´s disease model
Objective: Understand the molecular principles and identify genetic drivers underlying and mitigating the preventative effects of environmental enrichment on the unfolding of Parkinson´s disease (PD) pathology.…Fundamental limit of the alpha-synuclein immunohistochemistry using the endoscopic biopsy from the gastrointestinal tract as a biomarker for Parkinson disease: a case-control study
Objective: To investigate significance of the Lewy pathology in biopsy and surgical specimen in the gastrointestinal (GI) tract as an in-vivo biomarker for Parkinson disease (PD). Background: Alpha-synuclein…Serum lipid profile in Parkinsons disease patients from Southern Spain
Objective: Our first aim was to evaluate differences in the blood lipid profile levels between Parkinsons disease (PD) patients and healthy controls (HC). Secondly, in…Genetic, epigenetic and expression profiles in alpha-synucleinopathies
Objective: To determine whether each of the alpha-synucleinopathies has distinct methylation and/or expression profiles that distinguishes them from other disorders in this class. Background: The…
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