Inhibition of glucosylceramide synthase reduces pathology and improves cognition in synucleinopathy murine models
Objective: We investigated the merits of glucosylceramide synthase (GCS) inhibition as a potential treatment for synucleinopathies. Background: Mutations in GBA, the gene encoding glucocerebrosidase, are…Survival and risk of mortality of synucleinopathies: A 15 years population-based study (1991 – 2005)
Objective: To investigate the survival and mortality of synucleinopathies 15 years of study. Background: Limited data are available to estimate the mortality and the causes…Mitochondrial response precedes intracellular accumulation of α-synuclein in Parkinson’s disease
Objective: To investigate the expression of mitochondrial COX-IV during the progression of Parkinson's disease. Background: Parkinson's disease (PD) is a neurodegenerative disease characterized by the…Utility of the Mayo sleep questionnaire in predicting final autopsy diagnosis of alpha-synucleinopathy
Objective: To ascertain the utility of the MSQ in predicting final autopsy diagnosis of an alpha-synuleinopathy. Background: Idiopathic REM sleep behavior disorder (iRBD) is a…sFIDA: A sensitive diagnostic assay for quantification of α-synuclein aggregates
Objective: Optimizing of our sFIDA (surface-based fluorescence intensity distribution analysis) assay for specific detection and quantification of single α-synuclein aggregates. Background: Parkinson's disease (PD) is…Alpha-synuclein – super-resolution microscopy reveals potential new role of alpha-synuclein at the pre-synapse
Objective: Alpha-synuclein is a major key player in Parkinson's disease, however its physiological function still remains elusive. Using super-resolution microscopy this study aims to analyse…Gender-dependent behavioral and biochemical differences in the A53T genetic mouse model of Parkinson’s disease
Objective: The main aim of the present study was to investigate whether behavioral and biochemical differences may occur between male and female old (12-month-old) transgenic…Clinical phenotype of Parkinsonian patients with α-synuclein mutation: Our case report and review of the literature
Objective: To illustrate the case of a 60 years old woman with A53T point mutation derived Parkinson's disease (PD) and to review SNCA mutations phenotype,…Brain metabolic profile changes reflect subtle pathological alterations in different murine models of Parkinson’s disease
Objective: Understanding early, and therefore often subtle, disease processes in Parkinson's disease (PD) is essential for the development of disease modifying cures. But in patients,…The serum response factor SRF protect dopamine (DA) neurons in Parkinson’s disease partially by mediate autophagy through a beclin 1-dependent pathway
Objective: To investigate the level of serum response factor(SRF) in rotenone-induced Parkinson's disease(PD) model and PD patients, and explore the potential protective role and underlying…
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