Longitudinal Changes and Clinical utility of the Neurological Pupillary Index in De Novo Parkinson’s Disease
Objective: To characterize longitudinal changes in pupillometric parameters in de novo Parkinson’s disease and explore their associations with clinical severity and disease progression. Background: Automated…Heart Rate Variability in Early Parkinson’s Disease
Objective: This study aimed to investigate the clinical relevance of heart rate variability (HRV), which may indicate underlying autonomic nervous system activity, in patients with…Testing the body vs brain-first hypothesis in early PD: a cross-sectional study
Objective: To assess whether body vs brain-first PD phenotypes differ in their autonomic, motor and non-motor burden in their early stages. Background: A growing body…Unveiling the unusual: PNMA2 paraneoplastic syndrome
Objective: To present a rare case report Background: A 69 year old woman presented with progressive ptosis, change in voice (hypophonia), dysphagia, generalised weakness with…The Parkinson’s Impact Project: A Multimodal Longitudinal Study of Disease Development and Progression at the 23andMe Research Institute
Objective: Characterize the interactions between lifestyle, environmental, and genetic exposures on susceptibility to Parkinson’s disease (PD) and progression rates through a scalable remote web-based multimodal…Standardized Autonomic and Movement Assessment in Mexican Patients with Undetermined and Degenerative Progressive Parkinsonism: A Single-Center Experience
Objective: We proposed a unified and standard autonomic and movement evaluation to discriminate patients' Parkinsonism related to synucleinopathies from other conditions during a clinical office…Diagnosing Prodromal Synucleinopathies – What is the Role of Cardiac MIBG Scintigraphy?
Objective: We aimed to characterize cardiac MIBG uptake patterns in patients with an initial diagnosis of PAF (iPAF) and assess their role as a prognostic…Cerebellar peduncle microstructure and autonomic dysfunction in Parkinson’s disease
Objective: To investigate whether cerebellar peduncle microstructure is associated with autonomic dysfunction in Parkinson’s disease (PD). Background: Autonomic dysfunction is a common and disabling non-motor…Sudomotor Dysfunction in Patients With Normal and Abnormal Cardiac MIBG
Objective: We examined the pattern of sweat loss in patients with normal versus abnormal MIBG and considered the implications of this in predicting phenoconversion trajectory.…The Unholy Marriage Between Ogilvie Syndrome and Parkinson’s Disease
Objective: To demonstrate the dynamic interplay between advanced Parkinson’s disease (PD)–related colonic dysmotility and acute colonic pseudo-obstruction (ACPO; Ogilvie syndrome) and to highlight practical red…
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