Sympathetic tone abnormalities in subjects at risk for Parkinson’s Disease without evidence of nigrostriatal neurodegeneration: a multimodal biomarker study
Objective: To study autonomic dysfunction in subjects with idiopathic REM sleep behavior disorder (iRBD) and at least one pre-motor symptom of Parkinson's disease (PD). Background:…Heart-rate variability as a new marker for freezing predisposition in Parkinson’s disease
Objective: We aim to investigate for the first time whether it is possible to detect a predisposition for upcoming Freezing of Gait (FoG) events from…Synaptic density and α-synuclein oligomers in skin biopsies: differences between idiopathic and GBA-linked Parkinson’s disease
Objective: To compare α-synuclein oligomers and synaptic density (SD) in skin biopsies from PD and GBA-PD. Background: Previous research [1] reported α-synuclein oligomers within synaptic terminals of autonomic fibers in…Heart rate variability is affected by standing and medication intake in Parkinson’s disease
Objective: To evaluate the effect of levodopa and orthostatism on heart rate variability (HRV) in a sample of consecutive subjects with Parkinson's disease (PD). Background:…Comparison and analysis of pupillometer parameters between patients with drug naive Parkinson’s disease and controls
Objective: We compared the pupillary findings of drug-naïve Parkinson’s disease (PD) patients and controls to investigate the characteristics of pupillary light reflexes (PLR) in PD…Double labeling alpha-synuclein in labial minor salivary glands in Parkinson’s disease and idiopathic RBD patients
Objective: To investigate the presence of α-Syn immunostaining in minor salivary gland biopsies (MSGB) from patients with idiopathic Parkinson's disease (PD), idiopathic Rapid Eye Movement…Autonomic Symptoms as Predictors of Quality of Life in Parkinson’s Disease: A 5-year follow up study
Objective: The aim of this study was to investigate whether the autonomic symptoms could predict the quality of life of patients with PD. Background: Parkinson's…Clinical Features Associated with Dysautonomia in Prodromal Parkinson’s Disease
Objective: To compare clinical features between those with and without dysautonomia in a cohort with other prodromal Parkinson’s disease (PPD) markers. Background: Dysautonomia has been…A qualitative evaluation of the health-related quality of life impact on informal caregivers to patients with neurogenic orthostatic hypotension
Objective: This study aimed to explore the impact of caring for an individual with neurogenic orthostatic hypotension (nOH) through qualitative interviews with informal caregivers and…Increased epinephrine in the saliva of Parkinson’s disease patients: A preliminary observation
Objective: To investigate the levels of dopamine (DA), norepinephrine (NE), epinephrine (EPI) and serotonin (5-HT) in the saliva of Parkinson’s disease (PD) patients and compare…
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