Safety profile of pimavanserin therapy in elderly patients with neurodegenerative disease-related neuropsychiatric symptoms: a Phase 3b study
Objective: To evaluate the safety profile of pimavanserin in patients with neuropsychiatric symptoms related to neurodegenerative disease (NDD). Background: Patients with NDD including Parkinson’s disease…Evaluation of a novel Phosphodiesterase 5 inhibitor as a potential therapeutic agent in P301S transgenic mouse model of tauopathy.
Objective: In the current study, we evaluated a newly developed compound with a 1,3,5-trisubstituted pyrazoline scaffold with an improved PDE5 inhibitory potency as a potential…Phenotypic characterization of 104 patients with Progressive Supranuclear Palsy: A Tertiary care experience from South India
Objective: To prospectively evaluate and subtype the patients of Progressive supranuclear palsy being referred to a tertiary care movement disorders facility in South India. Background:…CSF tau reflects long-term outcome of patients with idiopathic normal pressure hydrocephalus: a longitudinal retrospective study.
Objective: To predict long-term clinical outcome of iNPH patients through a panel of neurodegeneration-related CSF biomarkers. Background: Idiopathic normal pressure hydrocephalus (iNPH) is a neurodegenerative…Incremental Hospitalizations and Associated Costs of Co-existing Dementia in Patients with Parkinson’s Disease Psychosis: An analysis of US Medicare Beneficiaries
Objective: To evaluate incremental hospitalizations and costs among Medicare patients with Parkinson's disease psychosis (PDP) vs. PDP+dementia (PDP+D). Background: Research examining hospitalizations and costs of…In vivo positive amyloid PET in a patient with PDD, always reliable?
Objective: To describe a singular case of an early-onset Parkinson disease (PD) patient with PD dementia who presented in vivo positive 18 F-Flutebetamol PET but…A vicious cycle of karyopherin abnormalities in synucleinopathies
Objective: This study aims to investigate the role of karyopherin abnormalities in the onset and progression of synucleinopathies. Background: Despite differences in clinical manifestations, Parkinson’s…Rapidly progressive dementia – catatonia – myoclonus in 80 years old patient: An unusual case
Objective: Objective:Sporadic Creutzfeldt-Jakob Disease (sCJD) will be challenging to differentiate from other diseases, like NMDA autoimmune encephalitis (AE). The classic rapidly progressive dementia phenotype that…Relationship between agricultural vulnerability to organic compound fungicides and herbicides and Parkinson’s disease incidence in rural population in northern India
Objective: In the Indian agricultural health study cohort, we evaluated the relationship between prospective exposures to organic fungicides and herbicides and the incidence of Parkinson's…Can medicinal mushrooms help to stabilize or improve cognitive function in Parkinson’s patients with mild cognitive impairment?
Objective: To explore whether the medicinal mushrooms Hericium erinaceus and Ganoderma lucidum may help to stabilize or improve cognitive function in Parkinson’s patients with mild…
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