Perinatal Dioxin Exposure and Dopaminergic Vulnerability in the Development of Motor Dysfunction Sequelae
Objective: To investigate the impact of dioxins on movement disorder development and the mechanisms increasing vulnerability to future motor dysfunction. Background: Dioxins are persistent organic…Gut Dysbiosis Alters Host Metabolism but Does Not Independently Induce Parkinson’s Disease Pathology
Objective: To determine whether gut dysbiosis alone is sufficient to induce Parkinson’s disease (PD) pathology and to investigate its impact on host metabolism. Background: Gut…Dietary Caffeic Acid Exhibits Neuroprotective and Neuromodulatory Effects in a Parkinsonian Rat Model by Mitigating Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis
Objective: This study investigated the neuroprotective and neuromodulatory effects of dietary caffeic acid (CA) in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinsonian rat model Background: Parkinson’s disease (PD)…A Long-Living Human Tissue Engineered Nigrostriatal Pathway as a Testbed to Study Parkinson’s Disease
Objective: To create a three dimensional (3D) long-living model of human tissue-engineered nigrostriatal pathway (TE-NSP) comprised of discrete somatic and axonal compartments recapitulating the native…Contribution of Dopamine Depletion, Cerebral Perfusion, and Cognition to Gait Dysfunction in Parkinson’s Disease
Objective: To explore the potential contribution of dopamine loss, perfusion deficit, and cognition to spatiotemporal gait parameters in patients with Parkinson's disease (PD). Background: Gait…Understanding the relationship between synaptic density and dopamine transporter availability in Parkinson’s disease
Objective: To evaluate how disease duration in PD affects the coupling of DAT (18F-FE-PE2I) and SV2A density (11C-UCB-J) in the nigrostriatal regions (where both tracers…Living Deep Brain Stimulation for External Control of Striatal Dopamine
Objective: To develop a therapeutic system to allow real time modulation of striatal dopamine release using a living electrode composed of optogenetically controlled dopaminergic neurons.…The Inhibition of Mitochondrial NLRP3 Inflammasome Decreases Dopaminergic Cell Death in a 6-OHDA Mouse Model of Parkinson’s Disease.
Objective: To evaluate the possible neuroprotective effects of mitochondrial NLRP3 inflammasome inhibition in a 6-hydroxydopamine mouse model of Parkinson's Disease. Background: Overactivation of brain immune…Tissue-Engineered Nigrostriatal Pathways: An Anatomically-Inspired Model of Synucleinopathy in Human Neurons
Objective: The objectives of this study were (1) to create a human cell-based three-dimensional neural network that recapitulates the discrete somatic and axonal compartments of…Exploring the Neuroprotective Effects of Diurnal Light Exposure in Early-Stage Parkinson’s Disease: A Longitudinal, Multi-Sensory Intervention Study
Objective: This study aims to explore the neuroprotective effects of controlled diurnal light exposure on neurodegeneration rates in early-stage PD patients, positing that light therapy…
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