MDS Abstracts

Abstracts from the International Congress of Parkinson’s and Movement Disorders.

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Articles tagged "Dopaminergic neurons"

  • 2024 International Congress

    Exploring the Neuroprotective Effects of Diurnal Light Exposure in Early-Stage Parkinson’s Disease: A Longitudinal, Multi-Sensory Intervention Study

    S. Putri, R. Fajar, E. Syafruddin (Gresik, Indonesia)

    Objective: This study aims to explore the neuroprotective effects of controlled diurnal light exposure on neurodegeneration rates in early-stage PD patients, positing that light therapy…
  • 2024 International Congress

    Loganic Acid Alleviates the Bidirectional Olfactory-Brain NLRP3 Inflammasome Activation and Rescues Dopaminergic Neurons in Experimental Models of Parkinson’s Disease

    S. Panda, P. Panja, V. Naidu (Guwahati, India)

    Objective: The study aimed to delineate the molecular mechanism involved in bidirectional olfactory-brain dysfunction through the NLRP3 inflammasome signaling activation in in-vitro and in-vivo model…
  • 2024 International Congress

    Neuroprotective Effect of Isoquercitrin in Rotenone Induced Parkinson’s Disease-Like Motor and non-motor Symptoms in Zebrafish

    KHA. Aran (Moga, India)

    Objective: The objective of study is to find out the effect of isoquercitrin, a plant-derived chemical, against Parkinson-like symptoms induced by rotenone in zebrafish.. Background:…
  • 2024 International Congress

    Bioreactor-produced iPSCs-derived Dopaminergic Neuron-containing Neural Microtissues Innervate and Restore Motor Function in a Dose-dependent Manner in a Parkinson Rat Model

    N. Prudon, L. Cordero-Espinoza, M. Abarkan, B. Gurchenkov, C. Morel, M. Lepleux, V. de Luca, N. Pujol, L. Milvoy, P. Morand, F. Moncaubeig, H. Wurtz, L. Poinçot, M. Demarco, A. Jonckeau, J. Plétenka, E. Luquet, K. Schmit, L. Piouceau, S. Guilbert, L. Manache-Alberici, M. Lanero, G. Dabee, T. Dufourd, J. Schroeder, K. Alessandri, E. Bezard, E. Faggiani, M. Feyeux (Bordeaux, France)

    Objective: To demonstrate the efficacy of a ready-to-graft 3D neural microtissue product – manufactured at large scale – as a therapeutically viable option to treat Parkinson’s…
  • 2024 International Congress

    Preclinical Studies: Investigating Serum-Based Exosomal miRNAs in Prodromal Drug-Induced Parkinson’s Disease

    M. Ahmad (Hyderabad, India)

    Objective: This work aims to elucidate the identification of homologs of miRNAs in a pronormal stage of Parkinson`s disease. Background: Parkinson's disease (PD) is defined…
  • 2024 International Congress

    Differences in Molecular and Ultrastructural profiles of astroglia and microglia in substantia nigra of two different mice strains in normal aging and experimental Parkinsonism

    P. Alladi, A. Abhilash, U. Bharti, R. Santhosh Kumar, M. Philip, B. Chandrasekhar Sagar (Bangalore, India)

    Objective: To examine whether the variable sensitivity of dopaminergic neurons of the substantia nigra pars compacta -SNpc- in C57BL/6J and CD-1 mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/ MPTP…
  • 2024 International Congress

    The functional and lipidome signature of GBA1 mutant dopaminergic neurons

    G. Uras, S. Lucas-Del-Pozo, F. Fierli, S. Koletsi, V. Lentini, P. Caboni, C. Manis, D. Di Lisa, A. Andolfi, L. Pastorino, A. Schapira (London, United Kingdom)

    Objective: The work presented here aims to link the lipidome changes leading to functional defects, and eventual cell death, in GBA1 mutant dopaminergic neurons derived…
  • 2024 International Congress

    LRRK2 I1371V Mutation: Unraveling Pathogenic Mechanisms in Dopaminergic Neurons via Membrane Fluidity & Calcium Dysregulation using PD Patient iPSCs

    I. Datta, S. Jagtap, V. Holla, N. Kamble, R. Yadav, P. Pal (Bengaluru, India)

    Objective: To estimate pathogenicity of LRRK2 I1371V mutation in PD patient iPSC-derived DA-neurons & assess underlying disease mechanisms involving membrane fluidity, Ca2+ dysregulation, & Rab8A/Rab10…
  • 2024 International Congress

    PARKIN gene replacement by AAV-mediated gene delivery as a therapeutic modality for PARKIN-deficient early-onset familial Parkinson’s disease

    N. Gattone, AJ. Gilsrud, S. Basu, T. Demarest, B. Wicks, E. Kostuk, D. Narendra, MG. Biferi, E. Ramsburg (Philadelphia, USA)

    Objective: Evaluate PARKIN gene replacement by adeno-associated virus (AAV) vector as a therapeutic modality in relevant disease models of early-onset Parkinson’s Disease (EOPD). Background: Biallelic…
  • 2024 International Congress

    Mapping the distribution of neurotransmitters to resting-state functional connectivity in patients with Parkinson’s disease

    W. Li, N. Lao-Kaim, R. Li, A. Martín-Bastida, A. Roussakis, G. Searle, N. Valle-Guzman, V. Dayal, D. Athauda, Z. Kefalopoulou, P. Mahlknecht, A. Church, K. Peall, H. Widner, G. Paul, T. Foltynie, R. Barker, P. Piccini (London, United Kingdom)

    Objective: To examine the associations between functional connectivity (FC), as measured by resting-state functional magnetic resonance imaging (rs-fMRI), and the spatial distribution of dopamine and…
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