Clinical Utility of DaT-SPECT as a Predictive Tool for the Development of Parkinson’s Disease and Related ɑ-synucleinopathies in REM-Behavior Disorder
Objective: The aim of this systematic review was to analyze the available literature and evaluate the efficacy of DaT-SPECT for the prediction of PD phenoconversion…Age-related characteristics of the clinical progression of Parkinson’s disease
Objective: To analysis of the rate of progression of the disease in PD according to the age of patients. Background: Although Parkinson's disease (PD) is…Automated MRI Biomarker Extraction for Parkinson’s Disease Using Attention-Based U-Net Segmentation
Objective: To evaluate a deep learning-based automated segmentation pipeline for extracting midbrain regions in MRI scans related to Parkinson’s disease. Background: Magnetic resonance imaging has…SIRT3 upregulation in nigral dopaminergic neurons preserves motor circuit integrity for anti-sarcopenia
Objective: To determine whether enhancing resilience of substantia nigra dopaminergic neurons preserves motor circuit integrity. Background: Degeneration and dysfunction of substantia nigra pars compacta (SNpc)…Neuroprotective Effects of Emodin Against Rotenone-Induced Parkinsonism Through Regulation of SIRT1-Mediated Inflammasome and Nrf2 Pathways
Objective: This study aimed to investigate the neuroprotective potential of emodin in a rotenone-induced PD model and to elucidate its underlying molecular mechanisms focusing on…L-DOPA Metabolism as a Function Related to the Potency of iPSC-Derived Dopaminergic Progenitor cells
Objective: This study aimed to elucidate how iPSC-derived dopaminergic progenitor cells (iPSC-DAPs) acquire the ability to metabolize L‑DOPA in vitro and to evaluate whether the…Continued Evaluation of Clinical Outcomes in Participants With Parkinson’s Disease Through 4 Years After Bemdaneprocel Administration
Objective: To report safety and clinical outcomes in participants with Parkinson’s disease (PD), 4 years after receiving bemdaneprocel. Background: Bemdaneprocel is an investigational cell therapy…Microglial Inflammatory Signaling Mediates Neuroimmune Dysregulation And Behavioral Dysfunction in A Parkinson’s Disease Model
Objective: To determine whether M1 microglial signaling via FAM19A3, CHI3L1, and VILIP-1 contributes to neuroinflammation, neuronal degeneration, and behavioral dysfunction in a Parkinson’s disease, and…The Protective role of Blood brain barrier-Vagal Interface in Parkinsonian pathology in mice
Objective: This study aimed to investigate whether vagal activity modulates BBB integrity and contributes to neurodegeneration and behavioral impairment in PD pathology. Background: Disruption of…Mechanistic study of PARP9-mediated mitochondrial transfer in regulating dopaminergic neuronal injury and neuroinflammation in Parkinson’s disease
Objective: To investigate PARP9 expression and localization in PD models, evaluate its effects on dopaminergic neuronal injury and microglial activation, and determine whether PARP9 regulates…
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