Cortical gamma oscillations as biomarkers for levodopa-induced dyskinesia
Objective: The aim of our study was to characterize cortical neuronal network activity in levodopa-induced dyskinesia in order to better understand the underlying pathophysiology and…Safety of Gocovri in Clinical Practice: One-year Post-launch Pharmacovigilance Data
Objective: To assess the real-world safety profile of Gocovri® (amantadine) extended release capsules one year post-launch. Background: Gocovri received FDA approval in August 2017 for…Nutritional status in patients with Parkinson’s disease and its relationship with the motor phenotype.
Objective: To determine the nutritional status in patients with Parkinson's disease and to relate it to the motor phenotype. Background: Parkinson disease (PD) is a…Serotonergic function in De Novo Parkinson’s Disease
Objective: We aimed to investigate the central serotonergic function in de novo PD and change in serotonergic function with dopaminergic medications. Background: While dopaminergic dysfunction…Mu opioid receptor agonism, not antagonism, for the treatment of L-DOPA-induced dyskinesia in Parkinson’s disease
Objective: To reappraise the role of the µ opioid receptor as a therapeutic target for L-DOPA-induced dyskinesia. Background: Parkinson’s disease (PD) is commonly treated with…Zonisamide ameliorates levodopa-induced dyskinesia via striatal cholinergic system in a rat model of Parkinson’s disease
Objective: To investigate the difference in results according to the mode of levodopa administration and the effect of zonisamide (ZNS) on striatal cholinergic system, we…Toning down SPNs to improve motor responses to dopaminergic stimulation in Parkinson’s disease
Objective: This study was aimed at examining whether decreasing the baseline SPN firing frequency towards the low activity found in normal conditions reduces LID. Background:…Crack Dancing: An Uncommon Drug-Induced Chorea
Objective: To report a unique case of cocaine induced choreiform dyskinetic movements with literature review of this condition. Background: Various abnormal movements have been known…A phase Ib trial studying the safety and tolerability of IRL790 in patients with Parkinson’s disease and levodopa-induced dyskinesia
Objective: The primary objective was to investigate the safety and tolerability of IRL790 in PD patients with LID in a randomized controlled trial. Background: IRL790…Clinical experiences in Whole systems Ayurveda Management of Parkinson’s Disease
Objective: PD Assessment of Ayurveda management using UPDRS -Motor, Hoehn & Yahr staging, Activity of Daily Living % (ADL). Background: Ayurveda holistic management comprises an…
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