How many and which kind of Parkinson’s disease patients need deep brain stimulation surgery? An evaluation based on clinical observation of patients with disease history of 15th year or more
Objective: To grasp real demand of deep brain stimulation (DBS) surgery in a substantial Parkinson's disease (PD) population. Background: DBS surgery has become frequently performed…Neuromelanin imaging is useful for monitoring disease progression in Parkinson’s disease and PARK2
Objective: Using neuromelanin (NM)-MRI, we analyzed whether disease severity and MF is associated with the degree of dopaminergic neuronal degeneration in the substantial nigra compacta…Levodopa induced dyskinesia and nicotinergic α4β2 acetylcholin receptor density: A multi-tracer imaging study
Objective: We investigated α4β2 acetylcholin receptor (nAChR) density in subjects with Parkinson's disease (PD) with and without levodopa-induced dyskinesia (LID) and its correlation with dopaminergic…Effects of safinamide in patients with Parkinson’s disease measured by Parkinson’s KinetiGraphTM
Objective: To objectively evaluate the effects of Safinamide in patients with Parkinson's (PD) by using the Parkinson's KinetiGraphTM (PKG), a newly developed tool for graphically…Wearable sensors and decision algorithms for advanced therapy referral in Parkinson’s disease
Objective: Pilot study to determine the impact of remote monitoring using objective, wearable sensors on the advanced therapy referral rate in patients with advanced Parkinson's…Opioid K receptor variant delays the onset of dyskinesias in Parkinson’s disease
Objective: To investigate the genetic factors modulating the timing of the onset of levodopa-induced dyskinesias (LIDs) in Parkinson's disease (PD). Background: Pathophysiological mechanisms underlying LIDs…Transcranial static magnetic field stimulation (tSMS) decreases motor cortex excitability in Parkinson’s disease OFF but not ON medication
Objective: To test the ability of transcranial static magnetic field stimulation (tSMS) to decrease motor cortex excitability in patients with Parkinson's disease OFF vs, ON…The clinical effects of mucuna and green tea in combination with levodopa-benserazide in advanced Parkinson’s disease: Experience from a case report
Objective: To describe the clinical effects of combined natural dopaminergic drugs with conventional levodopa therapy in a PD patient with motor and non-motor complications. Background:…Phenomenology of dyskinesias induced by subthalamic stimulation in Tourette syndrome
Objective: To describe the phenomenology of dyskinesias induced by subthalamic (STN) stimulation in refractory Tourette syndrome (TS). Background: Dyskinesias occurring following hemorrhagic events in the…The kinase Fyn mediates levodopa induced dyskinesias in Parkinson´s disease
Objective: To pharmacologically manipulate the kinase Fyn as a novel target to control levodopa induced dyskinesias. Background: The management of levodopa induced dyskinesias (LID) in…
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