Use of Mucuna Pruriens (M. Pruriens) in People with Parkinson’s Disease (PwPD)
Objective: To characterize M. pruriens use among local (primarily Argentinian) PwPD. Background: M. pruriens is a leguminous plant used in Ayurvedic medicine to treat Parkinsonism…Effects of Dance for Parkinson’s on Disease Severity, Functional Mobility, and Habitual Physical Activity: A Feasibility Study
Objective: To examine the feasibility and effects of a Dance for Parkinson’s Disease® (DfPD®) intervention on disease severity, functional mobility, fine manual dexterity, and habitual…A Novel Therapeutic Targeting the tPA-NMDAr Interaction for Multiple System Atrophy
Objective: LYS241, a first-in-class, humanized, and optimized monoclonal antibody, designed to inhibit the interaction between tissue plasminogen activator (tPA) and N-methyl-D-aspartate receptor (NMDAr), has demonstrated…Responsiveness of Sensor-Derived Measures From a Smartphone-Based Active Typing Test in the Phase 2b LUMA Study of Parkinson’s Disease
Objective: Investigate the measurement properties of exploratory sensor-derived measures (SDMs) from a smartphone-based typing test in the LUMA study of BIIB122/DNL151 for Parkinson’s disease (PD).…Responsiveness of a Smartphone-Based Sensor-Derived Composite Endpoint in a Phase 2b Study in Parkinson’s Disease (PD)
Objective: Development of a sensor-derived composite score (CS) for progression of motor symptoms in the LUMA study in PD. Background: LUMA (NCT05348785) is a randomized Phase 2b…Decentralized Clinical Trial of a Phase 3 Light Therapy Device for Parkinson’s Disease: Feasibility, Safety, and Efficacy
Objective: To demonstrate the feasibility of an entirely remote, decentralized clinical trial and evaluate the efficacy and safety of a light therapy device to treat…Beyond Relaxation: Can Self-Initiated Therapeutic Tremors Improve Functional Gait and ADL in Parkinson’s Disease?
Objective: The primary aim of this study was to investigate the effects of exercise with and without self-initiated unclassified therapeutic tremors (SUTT) on dynamic balance…Modulation of working memory in prodromal DLB by non-invasive brain stimulation of the striatum and cerebellum
Objective: We aimed to modulate working memory (WM) in patients with MCI with Lewy bodies (MCI-LB) by non-invasive stimulation of the striatum with or without…Repeated Scanning Ultrasound in an Alpha-synuclein Preformed Fibril model
Objective: To investigate the therapeutic potential of repeated scanning ultrasound (SUS)-mediated blood-brain barrier (BBB) opening in a mouse model of Parkinson’s disease (PD). Background: PD…Impact of Gastrointestinal Dysfunction Symptoms on Psychomotor Recovery Following 8-Week Aerobic Interval Training in Parkinson’s Disease – Preliminary Results
Objective: To investigate the impact of gastrointestinal dysfunction symptoms (GIDS) on psychomotor recovery following 8-week aerobic interval training (AIT) in Parkinson's disease (PD). Background: GIDS…
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