MDS Abstracts

Abstracts from the International Congress of Parkinson’s and Movement Disorders.

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Articles tagged "Microglia"

  • 2024 International Congress

    The role of LRRK2 in regulating microglial activity in Parkinson’s disease

    S. Brooker, A. Thomas, D. Krainc (Chicago, USA)

    Objective: To investigate the effects of pathogenic LRRK2 mutations on lysosomal function and phagocytic activity of microglia. Background: The LRRK2 G2019S mutation is one of…
  • 2024 International Congress

    Exploring the Therapeutic Potential of Microglial Modulation in Parkinson’s Disease: A Study on Structural Synaptic Plasticity

    F. Fares Taie, I. Taravini, L. Rela (Buenos Aires, Argentina)

    Objective: We aim to explore the role of glial cells in Parkinson's disease and assess whether modulating microgliafunction could offer therapeutic benefits. Specifically, we investigate…
  • 2024 International Congress

    Age-associated Changes in Microglial Morphology and its Role in Deciphering Susceptibility to Parkinson’s Disease

    S. Choudhury, P. Abhilash, P. Alladi (Bengaluru, India)

    Objective: To delineate the age-associated changes in microglial morphotypes in the substantia nigra pars compacta (SNpc) of C57BL/6J and CD-1 mice and alterations in response…
  • 2023 International Congress

    Honey prevented MPTP-induced oxidative stress, neuroinflammation and gliosis in adult male Swiss mice.

    F. Sulaimon, R. Ibiyeye, A. Imam, A. Imam, M. Ajao (Ilorin, Nigeria)

    Objective: To investigate the neuroprotective role of honey against oxidative stress and neuroinflammation induced by MPTP in adult male Swiss mice. Background: Oxidative stress and…
  • 2023 International Congress

    LRRK2 G2019S as a trigger of inflammatory signaling in patient-derived microglia

    K. Badanjak, P. Mulica, M. Tziortziou, S. Delcambre, S. Smajic, C. Venegas, M. Ali, T. Rolova, J. Koistinaho, P. Seibler, S. Cowley, J. Trinh, S. Pereira, P. Antony, E. Glaab, A. Grünewald (Esch-sur-Alzette, Luxembourg)

    Objective: This study explores the inflammatory processes in leucine-rich repeat kinase 2 (LRRK2)- microglia carrying the G2019S mutation and determines their contribution to Parkinson’s disease…
  • 2023 International Congress

    Preliminary evidence for evolution of myoinositol and N-acteylaspartate as biomarkers of disease severity in early-stage multiple system atrophy

    P. Trujillo, J. Iregui, K. Hett, A. Wynn, M. Donahue, C. Wong, D. Stamler, D. Claassen (Nashville, USA)

    Objective: To quantify the longitudinal evolution of metabolic indicators of gliosis and neuronal integrity in patients with multiple system atrophy (MSA) over one year. Background:…
  • 2022 International Congress

    Level of glial neurotrophic factor in the blood plasma depending on the duration of Parkinson’s disease

    B. Muminov, R. Matmurodov, E. Abduqodirov (Tashkent, Uzbekistan)

    Objective: To study the level of glial neurotrophic factor in the blood plasma depending on the duration of PD. Background: Study of the biochemical aspects…
  • 2022 International Congress

    The level of glial neurotrophic factor in blood plasma depending on the stage of Parkinson’s disease

    R. Matmurodov, M. Muminov, A. Abduqodirov, K. Khalimova (Tashkent, Uzbekistan)

    Objective: To study the level of glial neurotrophic disease in blood plasma in patients with Parkinson's disease (PD) depending on the stage Background: Parkinson's disease…
  • 2022 International Congress

    The cross-talk between microglia-derived exosomes and brain printing biometrics as a diagnostic approach for Parkinson’s disease prior to motor symptoms implications

    M. Anwar, M. Fathi (Cairo, Egypt)

    Objective: To highlight the efficiency of using microglia-derived exosomes (MDEs) in cross-talk with the BPB technique for the early diagnosis of Parkinson’s disease (PD) Background:…
  • 2022 International Congress

    Aerobic glycolysis regulates microglia-mediated neuroinflammation by promoting H3K9 lactylation in Parkinson’s disease

    Q. Qixiong, W. Hengming, W. Danlei, L. Jingyi, Q. Yi, Z. Jingwei, L. Jiangting (wuhan, China)

    Objective: This study aims to investigate the role of histone lactylation in microglia-mediated neuroinflammation and dopaminergic (DA) neuronal damage in Parkinson’s disease (PD). ​​​​​​​ Background: Augmented glycolysis induced by metabolic…
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