The role of Parkinson’s disease-associated RHOT1/Miro1 variants in mitochondrial dysfunction and impaired cellular quality control
Objective: In the present study we intent to investigate the effect of mutant Miro1 proteins on mitochondrial function and cellular quality control mechanisms in iPSC-derived…CHCHD2 maintains the MICOS and inhibits PINK1/Parkin mediated mitophagy in an experimental model of Parkinson’s disease
Objective: To illustrate the mechanism of CHCHD2 in regulating MICOS and mitophagy in Parkinson's disease.To illustrate the mechanism of CHCHD2 in regulating MICOS and mitophagy…Blood brain barrier dysfunction cause idiopathic adult onset ventriculomegaly?
Objective: Our hypothesis is BBB disruption causes idiopathic adult onset ventriculomegaly (IAOV) also, astrocyte specific mitochondrial dysfunction is associated with BBB damage. Background: The cause…Nrf2 pathway in patients with Parkinson’s disease
Objective: To demonstrate the activation of Nuclear factor erythroid-2-related factor 2 (Nrf2) pathway in PD patients. Background: Experimental data indicated the critical involvement of Nrf2…Protective effects of β-Nicotinamide Adenine Dinucleotide against motor deficits and dopaminergic neuronal damage in a Parkinson’s disease mouse model
Objective: The aim of our study is to explore whether nicotinamide adenine dinucleotide (NAD) replenishment could be beneficial on a 6-hydroxydopamine-induced Parkinson’s disease (PD) mouse…Protective effect of anodal transcranial direct current stimulation on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity in mice via modulating mitochondrial dynamics
Objective: The present study elucidated the neuroprotective effects of tDCS on the mitochondrial quality control pathway in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD mouse model. Background: Abnormal…Mitochondrial Complex 1, Sigma 1 Receptor and Synaptic Vesicle protein 2A density in early de novo patients with Parkinson’s Disease: pilot PET data
Objective: In this study, we evaluated the density of Mitochondrial complex 1 (MC1), sigma 1 receptor (s1R) and Synaptic Vesicle protein 2A (SV2A) in early…Using cognitive computing to identify existing drugs with potential to stabilize mitophagy pathways associated with Parkinson’s Disease
Objective: We applied IBM Watson for Drug Discovery (WDD), a cognitive computing platform that uses natural language processing, to identify compounds with the potential to…Another mitochondrial disease mimic: Two Case reports of adult riboflavin transporter deficiency (RTD) type 2 with muscle adenosine monophosphate (AMP) deaminase deficiency
Objective: To present two rare cases of RTD type 2 with co-existing AMP deaminase deficiency. Background: RTD, formerly known as Brown-Vialetto-Van Laere syndrome, is a…Arm levitation as an early manifestation in MELAS syndrome: A case report
Objective: Arm levitation in MELAS syndrome Background: MELAS syndrome has broad manifestations including stroke-like episodes, dementia, epilepsy, lactic academia, myopathy, recurrent headaches, hearing impairment, diabetes and short…
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