Unraveling the mechanisms of Tubulin Polymerization Promoting Protein TPPP/P25A degradation in oligodendrocytes
Objective: Our aim is to identify the proteolytic pathways responsible for the clearance of TPPP/P25A in oligodendrocytes, which may eventually represent potential therapeutic targets for…Neuroinflammation and Myelin changes in MSA-P evaluated using Advanced Diffusion MRI and Myelin Sensitive Imaging Techniques
Objective: To determine more specific neuropathologies of the white matter in patients with multiple system atrophy-parkinsonian variant (MSA-P) using multi-shell diffusion magnetic resonance imaging (MRI)…CHCHD2 mRNA levels in erythrocyte are reduced in patients with multiple system atrophy
Objective: To investigate CHCHD2 mRNA expression of erythrocyte in patients with multiple system atrophy (MSA). Background: Coiled-coil-helix-coiledcoil-helix domain containing 2 (CHCHD2) are reported to be associate with…Brain 5-HT1 receptor binding in multiple system atrophy: A [18F]-MPPF PET study
Objective: The primary objective was to compare brain 5-HT1a receptor binding between patients with multiple system atrophy (MSA) and healthy controls (HC). The secondary objectives…GCI-induced neurodegeneration and synucleinopathy in non-human primates
Objective: This study aimed at determining the potential to induce MSA pathology in non-human primates. Background: Aggregation of alpha-synuclein has been implicated in several neurodegenerative…Abnormal metabolic brain network in multiple system atrophy and progressive supranuclear palsy: a replication on a new European cohort
Objective: To identify characteristic metabolic brain patterns specific for multiple system atrophy (MSA) and progressive supranuclear palsy (PSP) in a new cohort of patients and…Increased lysosphingolipids levels in blood of patients with multiple system atrophy
Objective: To estimate activity of lysosomal enzymes and lysosphingolipids concentration in dry blood spot of patients with synuleinopathies: Parkinson’s disease (PD), dementia with Lewy bodies…Hypothalamic functional connectivity correlates with autonomic symptom burden in patients with Multiple System Atrophy
Objective: To investigate the association between autonomic symptom burden and hypothalamic functional connectivity in patients with MSA. Background: Multiple system atrophy (MSA) is a progressive…Pain in patients with multiple system atrophy: a pain-related evoked potential study
Objective: The purpose of this study was to investigate the pathophysiology of pain in patients with multiple system atrophy (MSA). Background: MSA is an atypical…Vocal cords electromyography abnormalities in multiple system atrophy phenotypes: relevance for the pathophysiology of stridor
Objective: To define correlations between vocal cords electromyography (EMG) abnormalities and stridor in multiple system atrophy (MSA) phenotypes. Background: MSA is a rare α-synucleinopathy characterized…