The Feasibility and Safety of Rehabilitation Program in Patients with Multiple System Atrophy
Objective: To evaluate the effects of rehabilitation on functional and clinical outcomes in patients with multiple system atrophy (MSA). Background: Currently, disease-modifying treatments for MSA…Atypical Parkinson: what can an outpatient Voice and Swallowing Clinic offer to patients
Objective: To examine the effectiveness of an Outpatient Voice and Swallowing Clinic in a tertiary referral centre for the management of swallowing of patients with…REM Sleep Behavior Disorder and Clinical Progression in Multiple System Atrophy
Objective: To investigate clinical characteristics of REM sleep behavior disorder (RBD) in multiple system atrophy (MSA) and evaluate associations with disease severity, autonomic dysfunction, and…GLP-1 Receptor Agonists in Movement Disorders: From Parkinson’s Disease to the Broader Spectrum — Mechanisms, Evidence, and Future Directions
Objective: To provide a comprehensive narrative review of the mechanistic rationale and clinical evidence for GLP-1 RA use across the spectrum of movement disorders, including…Home-based cerebellar transcranial stimulation for multiple system atrophy: A randomized trial
Objective: To evaluate whether home-based, remotely supervised cerebellar transcranial direct current stimulation (tDCS) can improve motor, cognitive and affective symptoms in patients with the cerebellar…Results from a Randomized, Double-Blind, Placebo-Controlled Study of ATH434 in MSA using CSF NfL as a Covariate
Objective: Evaluate efficacy and biomarker response of ATH434 in MSA, including CSF neurofilament light chain (NfL), a prespecified but previously unreported analysis using this disease-severity…A Novel Therapeutic Targeting the tPA-NMDAr Interaction for Multiple System Atrophy
Objective: LYS241, a first-in-class, humanized, and optimized monoclonal antibody, designed to inhibit the interaction between tissue plasminogen activator (tPA) and N-methyl-D-aspartate receptor (NMDAr), has demonstrated…Healthcare Resource Utilization and Costs of Multiple System Atrophy in the United States: An Observational Database Study
Objective: To assess the direct healthcare costs and healthcare resource utilization (HCRU) of MSA in the US commercially insured population. Background: MSA is a rare,…MobilityAPP: A randomized-controlled trial evaluating gait-focused physiotherapy in Parkinson’s disease and atypical parkinsonian syndromes
Objective: Effect on gait and balance of gait-focused physiotherapy compared to standard-of-care physiotherapy in patients with MSA, PSP and PD. Background: Physiotherapy is a crucial element…Device-aided Therapies in Multiple System Atrophy: Long-term Follow-up Case Series
Objective: To describe real-world long-term outcomes, tolerability, and complications of device-aided therapies (DAT) in people with multiple system atrophy (MSA; PwMSA) treated at a specialist…
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