Neuromelanin-Sensitive MRI as a Marker of Clinical Severity and Disease Burden in Parkinson’s Disease
Objective: To quantify associations between neuromelanin-sensitive MRI (NM-MRI) metrics and clinical severity and cumulative disease burden markers in Parkinson’s disease (PD). Background: NM-MRI visualises neuromelanin-containing…Multi-Sequence MRI-Based Machine Learning Model for Differentiating Parkinson Disease (PD) from Multiple System Atrophy (MSA)
Objective: To develop a multi-sequence MRI-based machine learning model differentiating PD from MSA. Background: MRI protocols capable of distinguishing PD from MSA are greatly needed.…Subtype-specific alterations of iron deposition and neuromelanin loss in the substantia nigra of Parkinson’s disease
Objective: To investigate the specific pathological changes in the substantia nigra (SN) across Parkinson’s disease (PD) subtypes, focusing on iron deposition and NM depletion both…Extracellular Neuromelanin Promotes Microglial Reactivity in Parkinson’s Disease
Objective: To investigate the interaction between neuromelanin (NM) and microglia in Parkinsons’s Disease (PD) using human post-mortem midbrain tissue and induced pluripotent stem cell (iPSC)…Neuromelanin Loss Is Associated with Increased Substantia Nigra Free-Water: a Longitudinal Study of Controls, RBD, and PD
Objective: To longitudinally characterize substantia nigra (SN) neuromelanin (NM) and free-water (FW) MRI biomarkers by comparing control, REM sleep behaviour disorder (RBD), and Parkinson’s disease…Assessment Of The Effect Of Sleep Deprivation And Essential Amino Acid Deficient Diet (Tryptophan) On Growth And Cognition In Wistar Rats
Objective: This study explores the interplay encompassing amino acids' roles, metabolic processes, growth, and the intricate relationships between sleep patterns, amino acid-deficient diet, and caffeine…AI based longitudinal changes in substantia nigra contrast and volume on neuromelanin MRI and its relation to clinical markers in a multi-site Parkinson’s disease study.
Objective: To apply an AI model in a multi-site longitudinal study to segment substantia nigra pars compacta (SNpc), perform longitudinal analysis, and quantify its association…Neuromelanin related 7T MRI of the locus coeruleus differs between Parkinson’s disease and controls
Objective: To compare the signal intensity of the substantia nigra and locus coeruleus on Magnetization Transfer 7T MRI between PD patients and healthy controls (HC)…Morphometric assessment of age-associated neuronal changes in the human locus coeruleus
Objective: To delineate the age-related changes in the neuronal size and neuromelanin (NM) intensity in autopsied tissues of human locus coeruleus (LC). Background: Many studies…Preliminary Report on Neuromelanin-Sensitive MRI Signal change after Allogeneic Bone marrow-derived Mesenchymal Stem Cells therapy: Phase IIa double-blind, randomized controlled trial
Objective: To select the most effective number of repeat doses of mesenchymal stem cells (MSC) delivered intravenously to slow the progression of Parkinson’s disease (PD).…
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