Enrollment Challenges and Strategies in Early-Stage Parkinson’s Disease Clinical Trials: Comparing Treatment-Naïve and Previously Treated Patient Populations
Objective: To evaluate enrollment rates and challenges in clinical trials of disease-modifying therapies (DMTs) for early-stage Parkinson's disease (PD), comparing treatment-naïve patients with those permitted prior symptomatic…Effects of Allogeneic Bone Marrow-Derived Mesenchymal Stem Cell Therapy on Motor Complications in Parkinson’s Disease
Objective: To evaluate the impact of intravenous (IV) allogeneic bone marrow-derived mesenchymal stem cell (allo-hMSC) treatment on motor complications in Parkinson’s disease (PD). Background: Motor…Long-term effects of a periodic intensive rehabilitation program in People with Parkinson’s Disease
Objective: This study aimed to examine the long-term effects of a periodic intensive rehabilitation program incorporating tele-tools on the progression of motor symptoms in people…NIH funds Gut-Brain Parkinson’s Disease Consortium
Objective: Describe the National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK) multicenter (UO1) Consortium on PD Gut-Brain Communication. Background: A 2024 Notice of Funding…Functional Activity of Apomorphine Relative to Dopamine at Dopamine Receptors: Findings from G Protein Coupled Receptor Biosensor Assays
Objective: Characterize the functional activity of apomorphine relative to dopamine using a modern panel of G protein-coupled receptor biosensor assays. Background: The structural similarity of…Establishing Clinical Education and Patient Support Programs for Continuous Subcutaneous Apomorphine Infusion (CSAI) in the United States
Objective: Establish an educational “Master Class” program to prepare health care providers (HCPs) for CSAI availability in the U.S. and develop educational support for people…Safety Profile of Opicapone in Elderly and Very Elderly Population
Objective: This study aimed to characterize the safety profile of opicapone (OPC) in the elderly and compare post-marketing safety between (A) very elderly patients (≥…Efficacy of LSVT-BIG Treatment Compared to Other Physiotherapy in Patients with Parkinson’s Disease: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Objective: We aim is to assess the efficacy of Lee Silverman Voice Treatment-BIG therapy (LSVT-BIG) compared to other physiotherapy in patients with Parkinson's Disease (PwP).…Medication therapy in Parkinson’s disease patients: a cross-sectional study at the University Medical Center at Ho Chi Minh City, Vietnam
Objective: To determine the rate of drugs prescribed to treat Parkinson's disease motor symptoms, the rate of the types of drug combinations, and the frequency…Comprehensive Multi-Platform Proteomic Analysis Identifies Novel Biomarkers for Parkinson’s Disease Diagnosis and Progression Monitoring
Objective: To replicate existing and identify novel protein biomarkers for PD diagnosis and progression. Background: Parkinson's disease (PD) lacks reliable biomarkers for early diagnosis and…
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