Dietary Caffeic Acid Exhibits Neuroprotective and Neuromodulatory Effects in a Parkinsonian Rat Model by Mitigating Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis
Objective: This study investigated the neuroprotective and neuromodulatory effects of dietary caffeic acid (CA) in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinsonian rat model Background: Parkinson’s disease (PD)…Relationship Between Improvement in “On” Time, Nonmotor Symptoms, and Quality of Life in Adults Treated With Foslevodopa/Foscarbidopa in Advanced Parkinson’s Disease
Objective: To determine if adults with advanced Parkinson’s disease (aPD) treated with a 24‑hour/day continuous subcutaneous foslevodopa/foscarbidopa (LDp/CDp) infusion who had ≥ 1‑hour improvement in…Efficacy And Safety of Fecal Microbiota Transplant for Parkinson’s Disease: A Systematic Review And Meta-Analysis
Objective: To evaluate the efficacy and safety of Fecal Microbiota Transplantation (FMT) in patients with Parkinson’s disease (PD). Background: FMT is a novel therapy for…Three-Year Single-Center Experience with Levodopa–Entacapone–Carbidopa Intestinal Gel in Advanced Parkinson’s Disease
Objective: To evaluate the efficacy of Levodopa-Entacapone-Carbidopa Intestinal Gel (LECIG) in advanced Parkinson’s Disease (APD). Background: LECIG infusion has been available in Romania since 2021.…Effects of Exogenous Melatonin on Sleep and Motor Symptoms in Parkinson’s Disease: A Systematic Review and Meta-Analysis
Objective: To evaluate melatonin's efficacy in enhancing sleep and motor symptoms in Parkinson’s disease (PD) through an updated systematic review and meta-analysis. Background: Sleep disturbances…Lysosomal Lipid Dysregulation in Parkinson’s Disease: Genetic and Medication Effects in CSF Metabolomics
Objective: Define lipid signatures in sporadic, LRRK2, and GBA1 PD and pre-manifest carriers and assess medication impacts. Background: Lysosomal dysfunction contributes to PD, particularly in…Privacy and Personalisation: Predicting Parkinson’s Severity with Federated Learning
Objective: To improve privacy and personalisation for artificial intelligence (AI), this work compared federated learning (FL) to a conventional, centralised system for predicting Movement Disorder…Facial Blendshape Index(FBI) for Quantification of Hypomimia on Parkinson´s Disease
Objective: To evaluate the validity of ExpressionTracker, an app generating personalized facial blendshapes, for objective quantification of hypomimia in patients with Parkinson’s disease (PD) [1].…Chronic DBS Stimulation’s effects after 1-hour off stimulation
Objective: This study investigates the changes in local field potential (LFP) activity during chronic deep brain stimulation (DBS) in patients with Parkinson's disease (PD) during…The East London Parkinson Disease Project: Higher Immune Activation found in Patients with Parkinson’s Disease Dementia from a Diverse Population
Objective: The scope of this work was to characterise the B-cell receptor repertoire of patients with Parkinson’s disease with dementia (PDD), cognitively resilient (PDR) and…
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