Risk Factors and Outcome of Dopamine Dysregulation Syndrome in a large Chinese Parkinson’s Disease Cohort
Objective: We conducted a large-sample study to investigate the clinical characteristics and related risk factors of DDS in China. In addition, we further followed up…The role of serotonergic mechanisms in the formation of levodopa-induced drug-induced dyskinesias in Parkinson’s disease
Objective: To study the quantitative content of serotonin and dopamine in the blood plasma of patients with Parkinson's disease and to conduct a clinical and…Alterations in gut microbiota composition in VPS35 associated PARK17 mouse model
Objective: This study explores whether host genetics such as specific VPS35 genetic variations linked to PD can shape the gut microbiome. Background: Heterozygous (D620N) mutation…Characterization of the Dnajc13 p.N860S mouse model, a physiological model of alpha-Synuclein overexpression
Objective: To characterize the Dnajc13 p.N860S mouse model of familial Parkinson’s disease Background: DNAJC13/RME-8 is a large, multi-domain molecular co-chaperone that facilitates membrane recycling and…Harnessing Machine Learning to Predict Balance Recovery: A Systematic Review of Training Protocols in Neurological Disorders
Objective: To systematically review training protocols integrating machine learning (ML) models in neurological rehabilitation, focusing on balance recovery predictions and their clinical applicability. Background: Balance…Joint Prediction of Motor and Non-motor Deep Brain Stimulation Outcomes using Quantitative Susceptibility Mapping
Objective: To jointly estimate motor and non-motor outcomes of deep brain stimulation using presurgical quantitative susceptibility maps. Background: Parkinson’s disease (PD) patients with motor complications…Utilizing Virtual Reality in Educational Programs for Parkinson’s Disease Rehabilitation: A Review of Current Literature and Future Directions
Objective: To evaluate the effectiveness of virtual reality (VR)-based educational programs in Parkinson’s disease (PD) rehabilitation and explore future directions for integrating VR into clinical…Interlaboratory cross-validation of CSF α-synuclein seeding aggregation assay for parkinsonisms
Objective: To evaluate CSF α-syn-SAA interlaboratory reproducibility in diagnosing Parkinson´s Disease (PD) and atypical parkinsonisms as well as interrogate the effect of changes in lot…Community Awareness of Parkinson’s Disease as a Driver of Stigma in Kilifi, Kenya
Objective: To gain a holistic understanding of stigma surrounding Parkinson’s disease in Kenya from the perspective of those who are stigmatised, and those who might…Lighting the Torch: Dating the Most Common Recent Ancestor of the PINK1 p.L347P Variant Linked to Parkinson’s Disease in Pacific Populations
Objective: To determine the generational age of the most recent common ancestor (MRCA) of patients homozygous for PINK1 p.L347P, to 1) Test the hypothesis that…
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