Preliminary Report on the efficacy of Allogeneic Bone marrow-derived Mesenchymal Stem Cells as a disease-modifying therapy for idiopathic Parkinson’s disease: Phase IIa double-blind, randomized controlled trial.
Objective: To select the safest and most effective number of repeat doses of allogeneic mesenchymal stem cells (MSC) delivered intravenously to slow the progression of…Cortical mean diffusivity changes in Parkinson’s disease with probable RBD
Objective: To investigate cortical mean diffusivity (cMD) as a sensitive measure to identify subtle microstructural cortical changes in Parkinson’s disease (PD) patients with probable REM…Design of a time-to-event study in GBA Parkinson’s Disease patients: Efficacy and safety of BIA 28-6156, an allosteric activator of beta-glucocerobridase (GCase)
Objective: To assess the efficacy of BIA 28-6156 in delaying clinically meaningful motor progression in PD patients who have a PD-risk associated variant in the…Impaired mitochondrial respiration as a peripheral tissue biomarker for stratifying idiopathic Parkinson’s disease
Objective: To determine whether structural and/or functional deficiencies of the mitochondrial respiratory chain (MRC) occur in the skeletal muscle of patients with idiopathic Parkinson’s disease…Parkinson’s Progression Markers Initiative (PPMI): Defining PD biology to accelerate PD therapeutics
Objective: The overall goal of PPMI is to identify, test and validate biomarkers of PD to accelerate therapeutic development throughout the PD continuum. Background: PPMI…Traveling through the telescope: a neuromuscular and a movement disorders reunion
Objective: We aim to raise awareness to an uncommon but possible combination of Parkinson Disease (PD) and Myasthenia Gravis (MG). Background: The co-occurrence of PD…Trends in the evaluation and management of constipation in patients with Parkinson disease
Objective: Explore common evaluation and management strategies for constipation in patients with Parkinson disease (PD) at a tertiary center. Background: PD is diagnosed based on…Optimizing DBS in PD: Investigating LFP beta power fluctuations in response to chronic stimulation
Objective: To determine if fluctuations in local field potential (LFP) beta power (BP) can be measured over time and whether the degree of fluctuation improves…Characterizing Hospital Admissions in Parkinson’s Disease: 10-Year Retrospective Study of Administrative Data in Alberta, Canada
Objective: Characterizing province-wide hospital admissions in persons with Parkinson’s disease (PD) to inform future healthcare improvement in this population. Background: Persons with PD have longer…Real-life heart rate assessment: a digital biomarker for autonomic dysfunction in early Parkinson’s disease?
Objective: To assess whether 1) tremor and dyskinesia affect photoplethysmography (PPG) data quality, and 2) heart rate (HR) analysis based on continuous PPG can be…
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