First-In-Human Single and Multiple Ascending Dose Trial Design of LY3962681, a Novel Intrathecally Delivered siRNA Targeting α-synuclein mRNA for the Treatment of Patients with Parkinson’s Disease
Objective: Development of a Phase 1 clinical trial evaluating LY3962681, a novel, intrathecally delivered siRNA directly targeting α-synucleinmRNA (SNCA) to reduce α-synuclein protein (ASYN), for the treatment of…Evaluation of neuroprotective effects of doxycycline in a primate model of PD
Objective: To evaluate the effects of doxycycline on the outcomes of 6-OHDA-induced Parkinson's disease in Sapajus apella monkeys. Background: Doxycycline (doxy) has been reported as…Bidirectional interplay between DBS and cognition in Parkinson’s disease: a systematic review
Objective: To evaluate the evidence regarding (1) deep brain stimulation (DBS) effectiveness in case of postoperative cognitive deterioration, (2) the impact of preoperative cognition on…AAV-mediated gene therapy for GBA-PD
Objective: Development of a gene therapy-based drug for treatment of GBA-PD, a genetic subtype of Parkinson’s disease Background: Mutations in GBA1, the gene encoding glucocerebrosidase…Deep brain stimulation contact selection using Neurophysiology and Artificial intelligence
Objective: To develop a machine learning (ML) algorithm capable of predicting the optimal deep brain stimulation (DBS) contact based on neurophysiology. Background: DBS is an…The impact of long-term continuous subcutaneous apomorphine infusion on the reduction of remaining medications in levodopa equivalent dosage and on increasing plasma vitamin B12 levels in patients with advanced Parkinson’s disease
Objective: To evaluate the plasma levels of vitamin B and homocysteine among 28 advanced PD patients with motor complications before and after continued used of…Pathological Mechanisms Associated with Atrazine-Induced Parkinson’s Disease Pathogenesis in Rat Model: The Rescue Role of Myricetin
Objective: This study aimed at investigating the mechanisms involved in the pathogenesis of Parkinson’s Disease in atrazine rat model of Parkinson’s Disease and the neuroprotective…Discriminating alpha-synuclein strains in Parkinson’s disease
Objective: To evaluate possible differences in the biological properties of alpha-synuclein fibrils derived from different patients with Parkinson's disease. Background: Parkinson’s disease (PD) is a…The role of extracellular vesicles in the progression of Parkinson’s disease
Objective: The objective of this study is to investigate the role of extracellular vesicles (EVs) in the progression of Parkinson’s disease Background: Parkinson’s disease (PD)…White matter abnormalities in motor subtypes of Parkinson’s disease
Objective: To evaluate white matter microstructural integrity in Tremor dominant Parkinson’s disease (TDPD) and postural instability and gait disturbance (PIGD) subtypes of PD to ascertain…
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