A Mixed Methods Study on the Impact of Reading the Graphic Memoir My Degeneration: A Journey Through Parkinson’s on Patients with Parkinson’s Disease
Objective: To explore the impact of reading a graphic memoir on patients’ knowledge, mental health, and attitudes about living with Parkinson Disease (PD). Background: In…Feasibility of telephonic voice samples to remotely monitor people with Parkinson’s disease residing in medically underserved rural regions
Objective: To explore the feasibility of collecting voice samples using digital voicemail in People with Parkinson’s disease (PwPD). Background: For many PwPD, the increased adoption…Striatal Subregion Analysis Associated with REM Sleep Behavior Disorder in Parkinson’s disease
Objective: Herein we evaluated the regional selectivity of presynaptic striatal dopaminergic denervation associated with RBD in drug-naive early PD. Background: REM sleep behavior disorder (RBD)…Can membrane association of α-synuclein aggregates lead to stress in the astrocytic endoplasmic reticulum?
Objective: To study the association extracellularly added wildtype-WT and A30P/A53T mutant α-synuclein aggregates with the astrocytic membrane and to evaluate the effect of these peptides…Evaluation of the effect of adding a mGlu2/3 orthosteric antagonist to a highly selective 5-HT2A antagonist on dyskinesia and psychosis-like behaviours in the MPTP-lesioned marmoset
Objective: To determine whether the therapeutic effect of serotonin 2A (5-HT2A) receptor antagonism on dyskinesia and psychosis may be reversed by orthosteric antagonism of metabotropic…Subcutaneous Foslevodopa/Foscarbidopa in Patients With Advanced Parkinson’s Disease: Results From a Randomized, Double-blind, Double-dummy Phase 3 Trial
Objective: To evaluate the efficacy and safety/tolerability of 24-hour/day continuous subcutaneous infusion (CSCI) of foslevodopa/foscarbidopa (a soluble formulation of levodopa/carbidopa prodrugs) vs oral levodopa/carbidopa in…Abnormal streamline density of the tremor network in tremor dominant Parkinson’s disease and Essential tremor plus syndrome
Objective: To evaluate streamline density (SD) of the basal ganglia-thalamocortical (BGTC) and cerebello-thalamocortical (CTC) network in tremor dominant Parkinson’s disease (TDPD) and essential tremor plus…Capturing the complexity of patients with parkinsonism: Baseline characteristics of participants in the PRIME-UK cross-sectional study
Objective: This cross-sectional study seeks to describe the symptomatology and health needs of a representative sample of people with parkinsonism, including those living with frailty,…Frequency of depression and predictors of mood change among caregivers of Parkinson’s disease patients
Objective: The aim of the present study was to analyze the frequency of depression in a cohort of caregivers of patients with Parkinson ́s disease…Developing infrastructure for a multi-arm multi-stage trial in Parkinson’s
Objective: To scope and develop infrastructure for the first multi-arm multi-stage (MAMS) platform trial for Parkinson’s disease, the Edmond J Safra ACT-PD initiative (EJS ACT-PD).…
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