Machine Learning-Driven Analysis of Epigenetic Signatures in Juvenile Huntington’s Disease: Investigating Histone Modification Dynamics
Objective: To investigate the role of histone modifications in Juvenile Huntington’s Disease (JHD) using machine learning, aiming to identify novel epigenetic biomarkers predictive of disease…Effect of ApoE ε4 allele on brain metabolism and cognition in non-demented Parkinson’s disease
Objective: This study aimed to explore the interplay between Apolipoprotein E (ApoE) ε4 allele, brain metabolism, and cognition in non-demented Parkinson’s disease (PD) patients. Background:…Risk factors in a population with high prevalence of Parkinson’s disease in Chile
Objective: The aim of this study was to investigate the frequency of environmental risk factors, comorbidities and family history in a population with Pakinson disease…Brain Energetics: Changes in Healthy Aging and Parkinson’s Disease
Objective: To identify in vivo bioenergetic alterations in healthy aging and Parkinson’s disease (PD). Background: PD-related cerebral metabolic alterations have been robustly characterized [1] and…Metabolic Imaging Correlates of Apathy in Parkinson’s Disease.
Objective: To investigate apathy-associated metabolic changes in Parkinson’s disease. Background: Apathy is a behavioral syndrome manifested as a decrease in goal-directed behaviors. It has been…Striatal dopamine- and basal forebrain cholinergic-dependent brain metabolism and cognition in Parkinson’s disease
Objective: To explore the interrelation of striatal dopamine, cholinergic basal forebrain volume, brain metabolism, and cognition in PD. Background: Parkinson’s disease (PD) involves multiple neurotransmitter…Seed-based Metabolic Networks and Time Series Variation based on Functional [18F]-FDG PET in Parkinson’s Disease
Objective: To analyse seed-based metabolic networks and time series variation in Parkinson’s disease with and without mild cognitive impairment based on functional PET (fPET) Background:…Effects of striatal dopamine depletion and altered brain metabolism on Parkinson’s disease
Objective: To investigate the relationship between striatal dopamine depletion, altered brain metabolism, motor deficits, and cognitive dysfunction in Parkinson’s disease (PD) Background: PD shows degeneration…The alteration of GABA and glutamate in Parkinson’s disease is related to motor executive dysfunction: a 7T-MRS study
Objective: To explore the possible metabolic alterations of primary motor cortices (M1) of Parkinson’s disease (PD) patients and prodromal PD using 7T proton magnetic resonance…Longitudinal Relationship Between Brain Metabolism and Clinical Changes in Huntington’s Disease
Objective: To understand the relationship between progression of the clinical symptoms and patterns of brain hypometabolism progression in a large cohort of Huntington’s disease (HD)…
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