Subthalamic Nucleus Oscillatory Coupling During Sleep is Impaired in Parkinson’s Disease and Associated with Memory Consolidation
Objective: To investigate whether the subthalamic nucleus (STN) supports sleep-dependent memory consolidation through hierarchical oscillatory coupling, and whether this mechanism is disrupted in Parkinson's disease…Multi-Omics Analysis Reveals Brain and Biofluid Molecular Changes Induced by Chronic Sleep Fragmentation in a Prodromal Parkinson’s Disease Mouse Model
Objective: To investigate the molecular mechanisms by which chronic sleep fragmentation accelerates the progression of prodromal Parkinson’s disease (PD). Background: Recent epidemiological studies suggest that…Identification of Alpha-synuclein Pathology in Idiopathic Rapid Eye Movement Sleep Disorder Participants by Seed Amplification Assay
Objective: To assess correlations between cerebrospinal fluid (CSF) α-synuclein seed amplification assay (synSAA) and the phenoconversion rate, timing, and final diagnosis of idiopathic rapid eye…Deep learning-derived progression network in isolated REM sleep behavior disorder
Objective: To identify and validate a progression-sensitive network biomarker for iRBD (RBDPN) using resting-state functional MRI (rs-fMRI) and deep learning (DL). Background: iRBD is a…Distribution of Chronotypes in Parkinson’s Disease and its association with Pathological Sleepiness
Objective: To study the distribution of chronotypes in Veterans with Parkinson's disease (PD); and its association with pathological sleepiness. Background: Excessive daytime sleepiness is a…Understanding Sleep-wake Disturbances in Dementia with Lewy Bodies Using Parametric and Non-parametric Measures in Wrist Actigraphy
Objective: To assess rest-activity and circadian rhythm stability in Dementia with Lewy bodies (DLB) and their relationship with cognitive, behavioural, and quality of life measures.…Racial Disparities in Hospitalization Characteristics among Native Hawaiians, Pacific Islanders and Asian American Subgroups with Restless Legs Syndrome
Objective: To determine if patient characteristics differ among Native Hawaiians/Pacific Islanders (NHPI), Asian American (AA) subgroups, and Whites who were hospitalized with Restless Leg Syndrome…Dysconnectivity Profiles of Raphe Nuclei in Parkinson’s Disease: From Prodromal to Advanced Stage
Objective: To investigate the functional connectivity changes of dorsal raphe (DR) and median raphe (MR) nucleus in patients with PD from the prodromal to advanced…Plasma biomarkers in iRBD patients serve as potential markers of early PD and motor severity
Objective: We aimed to investigate biomarkers of inflammation and neuroaxonal damage in people with isolated REM sleep behaviour disorder (iRBD) compared to controls, and understand…Utilising multiple murine models to investigate sleep and circadian system dysfunction in PD
Objective: We aimed to investigate the impact of alpha-synuclein aggregation and spreading, and nigrostriatal dopaminergic degeneration on sleep homeostasis and circadian function. Background: Sleep dysfunction…
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