Juvenile-Onset Parkinsonism With Bilateral Striatal Necrosis Associated With a Pathogenic MT-ND3 Mitochondrial Variant
Objective: To report a case of juvenile-onset parkinsonism associated with bilateral striatal necrosis and a pathogenic MT-ND3 mitochondrial DNA variant, emphasizing an atypical mitochondrial phenotype…Neuroinflammation and neurodegeneration biomarkers in Parkinson’s disease: integration of neuroimaging and fluid markers
Objective: To investigate the association between serum and cerebrospinal fluid (CSF) levels of NfL and GFAP and dopaminergic degeneration measured by 123I-ioflupane SPECT (DaTSCAN) in…Handwriting in PRKN-PD: A Study of Movement Control
Objective: To explore differences in movement control between PRKN-PD and gene-negative YOPD patients using a structured handwriting task. Background: Idiopathic Parkinson’s disease (IPD) symptoms are…Dopamine Transporter Imaging as Monitoring Biomarker in Parkinson’s Disease
Objective: To investigate the longitudinal relationship between changes in dopamine transporter single-photon emission computed tomography (DaT SPECT) and changes in motor symptom severity in Parkinson’s…Impact of Striatal Degeneration on Patient Reported Symptoms in Idiopathic Normal Pressure Hydrocephalus
Objective: To compare the subjective presenting motor (MS) and nonmotor symptoms (NMS) in subjects with idiopathic normal pressure hydrocephalus (iNPH) with and without striatal degeneration…Impact of Striatal Degeneration on Clinical Phenotype in Idiopathic Normal Pressure Hydrocephalus: A Comparative Analysis
Objective: To compare the clinical phenotype between patients with normal and abnormal dopamine transporter scan (DaTscan) in probable and definite idiopathic normal pressure hydrocephalus (iNPH).…Effects of ATH434, a Clinical-Phase Small Molecule with Moderate Affinity for Iron, in a Parkinson’s Disease Model in Macaques
Objective: (1) Determine whether oral ATH434 improves motor performance in a non-human primate hemiparkinasonian model when administered after symptom onset. (2) Relate observations to changes…Automated VMAT2 [18F]AV-133 PET analysis in Parkinson’s disease
Objective: To evaluate a fully automated image analysis pipeline to process vesicular monoamine transporters type 2 (VMAT2) [18F]AV-133 tracer positron emission tomography (PET) images, by…Blood NfL can track progression in multiple system atrophy
Objective: To validate the role of NfL for disease progression, severity and subject trial selection in MSA. Neurofilament light (NfL) was explored in this regard though…Network attack tolerance: A resilience proxy for Parkinson’s disease?
Objective: To investigate if individual capacity in network attack tolerance moderates the relationship between striatal dopamine loss and symptom severity in PD. Background: It was…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.