Smartwach Actigraphy for Detection of REM Sleep Behavior Disorder: The dBM-DEV Study
Objective: To evaluate feasibility and performance of multi-night at-home recordings using a smartwatch to (1) detect REM sleep behavior disorder (RBD) compared with polysomnography (PSG)…Isolated REM Sleep Behavior Disorder is Associated with Altered Nocturnal Skin Temperature Dynamics
Objective: To investigate skin temperature dynamics in the peri-sleep onset period in patients with isolated REM Sleep Behavior Disorder (iRBD). Background: Increases in peripheral skin…Identification of Alpha-synuclein Pathology in Primary Tauopathies by Seed Amplification Assay
Objective: To assess intravitam frequency and type of misfolded α-synuclein aggregates (syn-seeds) in participants with clinically defined primary tauopathies, such as progressive supranuclear palsy (PSP)…Identification of Alpha-synuclein Pathology in Dementia with Lewy Body Participants by Seed Amplification Assay
Objective: To assess frequency and type of misfolded α-synuclein aggregates (syn-seeds) in cerebrospinal fluid (CSF) from dementia with Lewy bodies (DLB) participants by means of…Identification of Alpha-synuclein Pathology in Idiopathic Rapid Eye Movement Sleep Disorder Participants by Seed Amplification Assay
Objective: To assess correlations between cerebrospinal fluid (CSF) α-synuclein seed amplification assay (synSAA) and the phenoconversion rate, timing, and final diagnosis of idiopathic rapid eye…Defining a Population-Based Cohort of Individuals with Probable REM Sleep Behavior Disorder
Objective: To identify a large population-based probable REM sleep behavior disorder (pRBD) cohort of women who are at risk of phenoconversion to Parkinson’s disease (PD)…A highly specific skin α-synuclein seed amplification assay for screening of synucleionpathies
Objective: To evaluate the performance of a skin α-synuclein seed amplification assay (skin_synSAA) as a screening test using samples from movement disorder subjects with uncertain…Cerebellar α-Synucleinopathy Contributes to Gait and Balance Impairment in Parkinson’s Disease
Objective: To determine whether cerebellar α-synuclein (α-syn) pathology contributes to the onset and progression of postural instability and gait difficulty (PIGD)-like motor deficits in Parkinson’s…Large-Scale Shotgun Mass Spectrometry in Parkinson’s Disease Plasma Identifies Novel Biomarker Candidates
Objective: To identify novel Parkinson’s disease (PD) blood biomarkers using unbiased shotgun mass spectrometry. Background: PD is a common neurodegenerative disorder diagnosed based on its…Dietary and Environmental Risk Factors of Parkinson’s Disease: An Integrated Network Pharmacology Approach
Objective: To investigate dietary and environmental determinants of Parkinson’s disease (PD) and related mortality by integrating large-scale clinical phenotyping with network pharmacology and molecular docking…
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