Large-Scale Shotgun Mass Spectrometry in Parkinson’s Disease Plasma Identifies Novel Biomarker Candidates
Objective: To identify novel Parkinson’s disease (PD) blood biomarkers using unbiased shotgun mass spectrometry. Background: PD is a common neurodegenerative disorder diagnosed based on its…Dietary and Environmental Risk Factors of Parkinson’s Disease: An Integrated Network Pharmacology Approach
Objective: To investigate dietary and environmental determinants of Parkinson’s disease (PD) and related mortality by integrating large-scale clinical phenotyping with network pharmacology and molecular docking…smSAA: developing a quantitative seed amplification assay with single molecule spectroscopy
Objective: Alpha-synuclein seed amplification assays (SAA) are highly sensitive and specific for detecting endogenous alpha-synuclein (Syn) seeds and are emerging as diagnostic tools for early…Disassembly of α-Synuclein Aggregates by the All-D-peptide PRI-101: Preclinical Efficacy in Vitro and in Vivo.
Objective: To develop a disease-modifying therapy for Parkinson’s disease (PD) and related synucleinopathies by eliminating intracellular, toxic, and seeding-competent aggregate species of α-synuclein (α-syn). Background:…Regional α-Synuclein Seeding Activity in Parkinson’s disease and Multiple System Atrophy
Objective: This study aimed to profile regional α‑synuclein (α-syn) seeding activity in postmortem brains from Parkinson’s disease (PD) and multiple system atrophy (MSA) and to…Underestimation of Nighttime Sleep Symptoms in Isolated RBD is Associated with Increased Risk of Phenoconversion to Synucleinopathy: A North American Prodromal Synucleinopathy Consortium Study
Objective: To determine whether mismatch between participant (PT) self-perceived and bed partner (BP)–reported sleep symptoms is associated with risk of phenoconversion to synucleinopathy. Background: Patients…Sex Differences in the Reported Prodromal Symptoms of Parkinson’s Disease (PD) in the Fox Insight Cohort
Objective: To identify differences in the self-reported prodromal symptoms of male vs female persons with PD (PwPD) in the Fox Insight (FI) cohort. Background: Early…Real-Time Quaking-Induced Conversion Detection of Tear Fluid α-Synuclein as a Potential Biomarker for Parkinson’s Disease
Objective: To detect α-synuclein (aSyn) in tear fluid and to evaluate the clinical characteristics of aSyn-positive patients. Background: Parkinson's disease (PD) is an α-synucleinopathy. Pathological…Clinical feasibility of a semi-automated Olfactometry System in α-Synucleinopathies
Objective: To evaluate the feasibility, performance, and diagnostic accuracy of a semi-automated olfactometry system (NOS-DX1000) for standardized assessment of olfactory dysfunction in α-synucleinopathies. Background: Olfactory…Serum Nutritional Biomarkers Associated with Isolated REM Sleep Behavior Disorder and α-synucleinopathy Phenoconversion
Objective: To investigate the serum nutritional markers in patients with isolated REM sleep behavior disorders (iRBD) and evaluate their associations with the risk of phenoconversion to α-synucleinopathies. Background:…
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