Sex Differences in the Reported Prodromal Symptoms of Parkinson’s Disease (PD) in the Fox Insight Cohort
Objective: To identify differences in the self-reported prodromal symptoms of male vs female persons with PD (PwPD) in the Fox Insight (FI) cohort. Background: Early…Real-Time Quaking-Induced Conversion Detection of Tear Fluid α-Synuclein as a Potential Biomarker for Parkinson’s Disease
Objective: To detect α-synuclein (aSyn) in tear fluid and to evaluate the clinical characteristics of aSyn-positive patients. Background: Parkinson's disease (PD) is an α-synucleinopathy. Pathological…Clinical feasibility of a semi-automated Olfactometry System in α-Synucleinopathies
Objective: To evaluate the feasibility, performance, and diagnostic accuracy of a semi-automated olfactometry system (NOS-DX1000) for standardized assessment of olfactory dysfunction in α-synucleinopathies. Background: Olfactory…Serum Nutritional Biomarkers Associated with Isolated REM Sleep Behavior Disorder and α-synucleinopathy Phenoconversion
Objective: To investigate the serum nutritional markers in patients with isolated REM sleep behavior disorders (iRBD) and evaluate their associations with the risk of phenoconversion to α-synucleinopathies. Background:…Smartwach Actigraphy for Detection of REM Sleep Behavior Disorder: The dBM-DEV Study
Objective: To evaluate feasibility and performance of multi-night at-home recordings using a smartwatch to (1) detect REM sleep behavior disorder (RBD) compared with polysomnography (PSG)…Isolated REM Sleep Behavior Disorder is Associated with Altered Nocturnal Skin Temperature Dynamics
Objective: To investigate skin temperature dynamics in the peri-sleep onset period in patients with isolated REM Sleep Behavior Disorder (iRBD). Background: Increases in peripheral skin…Identification of Alpha-synuclein Pathology in Primary Tauopathies by Seed Amplification Assay
Objective: To assess intravitam frequency and type of misfolded α-synuclein aggregates (syn-seeds) in participants with clinically defined primary tauopathies, such as progressive supranuclear palsy (PSP)…Identification of Alpha-synuclein Pathology in Dementia with Lewy Body Participants by Seed Amplification Assay
Objective: To assess frequency and type of misfolded α-synuclein aggregates (syn-seeds) in cerebrospinal fluid (CSF) from dementia with Lewy bodies (DLB) participants by means of…Identification of Alpha-synuclein Pathology in Idiopathic Rapid Eye Movement Sleep Disorder Participants by Seed Amplification Assay
Objective: To assess correlations between cerebrospinal fluid (CSF) α-synuclein seed amplification assay (synSAA) and the phenoconversion rate, timing, and final diagnosis of idiopathic rapid eye…Defining a Population-Based Cohort of Individuals with Probable REM Sleep Behavior Disorder
Objective: To identify a large population-based probable REM sleep behavior disorder (pRBD) cohort of women who are at risk of phenoconversion to Parkinson’s disease (PD)…
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