Paradoxical Association of Kinetics of α-Synuclein Seed Amplification 24-hrs Assay and Clinico-Pathological Markers of Parkinson’s disease
Objective: To investigate the association between baseline α-synuclein seed amplification assay (SAA) parameters and clinical and biomarker features of Parkinson’s disease (PD) at baseline and…Real world application of alpha-synuclein skin biopsy in the diagnosis of synucleinopathies at a tertiary care center
Objective: The goal of this study is to review the real-world application of alpha-synuclein skin biopsy at a tertiary care center. Background: Synucleniopathies including Parkinson’s…Validation of CSF Alpha-synuclein SAA in an Autopsy Cohort with Systemic Assessment of Lewy Pathology Including the Body
Objective: Based on the recent recommendations by international neuropathologists [1], we attempted to evaluate the diagnostic accuracy of cerebrospinal fluid (CSF) alpha-synuclein (α-syn) seeding amplification…Dopaminometer: A Smartphone-Based Application to Predict Striatal Dopaminergic Deficit in Prodromal and Manifest Parkinson’s disease
Objective: To assess the feasibility of a smartphone-based application (“Dopaminometer”) for predicting abnormal vs. normal dopamine transporter (DaT) scans and dopaminergic ratios in individuals with…Impact of Skin Biopsy Detection of Phosphorylated Alpha-Synuclein and its Distribution Patterns on the Diagnosis of Synucleinopathies
Objective: To assess how skin biopsy detection of phosphorylated alpha-synuclein (P-SYN) and its distribution pattern impact the diagnosis of synucleinopathies, such as Parkinson’s disease (PD),…Pathology Meets Clinical Practice: Unveiling the Pathological Evidence of Clinical Signs in Multiple System Atrophy
Objective: This study aimed to evaluate the pathological evidence of the core and supportive clinical features of multiple system atrophy (MSA) based on The Movement…Biological Characteristics of Individuals with RBD: A Multicenter Prospective Longitudinal Cohort
Objective: Examine baseline clinical and biological characteristics of participants with polysomnography-confirmed REM Sleep Behavior Disorder (RBD). Background: RBD is an early manifestation of underlying synucleinopathy…Plasma Neurofilament Light Chain and Orthostatic Hypotension in Isolated REM Sleep Behavior Disorder: A Biomarker for α-Synucleinopathy Progression
Objective: This study aims to assess plasma NfL levels in iRBD and their utility in detecting early neurodegenerative changes. Background: Rapid-Eye-Movement (REM) sleep behavior disorder…What Moves in the Night: Differences in Dream Quality Between REM Sleep Behavior Disorder and Trauma Associated Sleep Disorder
Objective: Explore differences in dream quality between REM Sleep Behavior Disorder (RBD) and Trauma Associated Sleep Disorder (TASD). Background: Idiopathic RBD is known to progress…LED Light as an Inductor of Optogenetic Activation of Astrocytes in Multiple System Atrophy
Objective: The pathogenesis of Multiple System Atrophy (MSA) involves the spread of misfolded α-synuclein from nerve cells to glia and dysfunction of mitochondria and proteasomes,…
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