Objective: To investigate the potential predictive factors of postoperative delirium after deep brain stimulation surgery for Parkinson’s disease (PD).

Background: Subthalamic nucleus deep brain stimulation (STN-DBS) is an effective treatment for medically refractory PD patients. Postoperative delirium (POD) is one of the common complications of STN-DBS surgery and often leads to further problems. 

Methods: A retrospective database and chart review of patients with PD implanted bilateral STN-DBS in our hospital between August 2015 and November 2016 was conducted. Diagnosis of POD was retrospectively made based on chart review or the Delirium Rating scale (DRS) at postoperative day one. Patients were classified into two groups based on presence of POD, and preoperative scores of the Mini Mental State Examination (MMSE), Frontal Assessment Battery (FAB), Japanese Version of The Montreal Cognitive Assessment (MoCA-J), Hamilton Depression Rating Scale (HDRS), the United Parkinson Disease Rating Scale (UPDRS), and Levodopa equivalent daily dose (LEDD) were compared between two groups. A two-tailed t-test was applied for statistical analysis. 

Results: Forty-eight patients (23 male and 25 female) were included in this study. The average disease duration and average age were 13±4.0 years and 62 ±7.9 years, respectively. From this cohort 17 patients developed POD (35%). Patients with POD showed significantly lower MoCA-J score (p<0.05). Age, disease duration, preoperative LEDD, FAB, MMSE, HDRS, UPDRS PartⅢ ON-state and OFF-state were not significantly different between two groups.

Conclusions: This study suggests that lower MoCA-J score may be risk of POD. 

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MDS Abstracts - https://www.mdsabstracts.org/abstract/postoperative-delirium-after-deep-brain-stimulation-surgery-for-parkinsons-disease/