Category: Other
Objective: To determine the frequency of hypertension (HBP) and type 2 diabetes mellitus (T2DM) as comorbidities in the Nigerian PD Research network (NPDR) cohort, and explore the relationship to PD-related clinical parameters and motor phenotype.
Background: HBP and T2DM are associated with a high risk of atherosclerotic cardiovascular disease. Both conditions share disease mechanisms such as inflammation with Parkinson’s disease (PD).
Method: The NPDR network is an ongoing national project recruiting persons with PD (defined by the United Kingdom PD Society Brain Bank criteria) into a disease registry. Demographic, clinical and disease-specific motor and non-motor parameters are documented at baseline enrolment. In this report, we present demographics, data on the presence of a diagnosis of HBP and/or T2DM, MDS-UPDRS Part III scores, and motor phenotype (based on Stebbin’s method).
Results: Data for 1880 (of 1891 registry participants with PD) was available for this report, and comprised 1366 (72.7%) males and 514 (27.3%) females. The mean (SD) age at study (AAS) was 63.8 (10.1) years, mean age at onset (AAO) of PD was 59.8 (10.4) years, MDS-UPDRS Part III score of 40.2 (19.2), and median Hoehn and Yahr stage of 2.0. The frequency of HBP was 44.4% (n = 834), and T2DM 3.9% (n=74). The frequency of HBP was marginally higher in females (247, 48.1% v. 587, 43.0% in males; p=0.048). The frequency of T2DM was 4.9% in females (n=25) and 3.6% in males (n=49) (p=0.21). Persons with PD and comorbid hypertension were significantly older at onset of PD (p<0.001), at the study baseline (p<0.001), but had similar motor severity (p>0.05), whereas AAO and AAS were similar in persons with and without T2DM (p>0.05). The MDS UPDRS Part III score was slightly lower in co-morbid T2DM (35.7), p=0.04). There was no significant difference in burden of HBP and T2DM regarding motor phenotype. HBP in PIGD-PD (46.7%, 269/576), compared to TD-PD (43.2%, 457/1058) and ID-PD (43.9%, 108/246); p>0.05. T2DM was present in 4.2% of TD-PD (44/1058), 3.6% of PIGD-PD (21/576), and 3.7% of ID-PD (9/246); p>0.05.
Conclusion: The burden of hypertension amongst pwPD is similar to reports for similar age groups in our population. The potential for increased cardiovascular outcomes from these comorbidities warrants intentional strategies for early identification and management in pwPD in Nigeria.
References: 1. Ojo OO, Abubakar SA, Iwuozo EU, Nwazor EO, Ekenze OS, Farombi TH, et al. The Nigeria Parkinson Disease Registry: Process, Profile, and Prospects of a Collaborative Project. Mov Disord. 2020 Aug;35(8):1315-1322.
2. Stebbins GT, Goetz CG, Burn DJ, et al. How to identify tremor dominant and
postural instability/gait difficulty groups with the movement disorder society unified Parkinson’s disease rating scale: comparison with the unified Parkinson’s disease rating scale. Movement Disorders. 2013 May 1;28(5):668-70
3. Odili AN, Chori BS, Danladi B, Nwakile PC, Okoye IC, Abdullahi U, Nwegbu MN, Zawaya K, Essien I, Sada K, Ogedengbe JO, Aje A, Isiguzo GC. Prevalence, Awareness, Treatment and Control of Hypertension in Nigeria: Data from a Nationwide Survey 2017. Glob Heart. 2020 Jul 10;15 (1):47. doi: 10.5334/gh.848. PMID: 32923341; PMCID: PMC7427662.
To cite this abstract in AMA style:
E. Iwuozo, O. Ojo, O. Agabi, N. Okubadejo, NPD. Research Network. Co-morbid Hypertension and Diabetes and the Relationship to Parkinson’s Disease Motor Phenotype in the Nigeria Parkinson’s Disease Research Network Registry [abstract]. Mov Disord. 2024; 39 (suppl 1). https://www.mdsabstracts.org/abstract/co-morbid-hypertension-and-diabetes-and-the-relationship-to-parkinsons-disease-motor-phenotype-in-the-nigeria-parkinsons-disease-research-network-registry/. Accessed June 15, 2025.« Back to 2024 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/co-morbid-hypertension-and-diabetes-and-the-relationship-to-parkinsons-disease-motor-phenotype-in-the-nigeria-parkinsons-disease-research-network-registry/