Objective: The aim of this study was to investigate the effects of two types of physical training on depressive-like behavior and pro-BDNF, BDNF and its receptor, TRKB levels in the brain of mice submitted to an animal model of PD induced by 6-hydroxydopamine (6-OHDA).

Background: Depression is a common neuropsychiatric disorder in Parkinson’s disease (PD). Many studies have suggested that physical exercise has antidepressant effects. It increases brain-derived neurotrophic factor (BDNF) levels and prevents against neurodegenerative diseases. However, different forms of training may promote alterations differently on the brain.

Methods: C57 black mice were submitted to 60 days of running on treadmill, or strength exercise, and 24 hours after the last physical exercise session, the PD was induced by the striatum administration of 6-OHDA. Seven days after 6-OHDA injection, depressive-like behavior and apomorphine-induced rotational behavior were evaluated.

Results: The levels of pro-BDNF, BDNF, and TRKB were measured in the striatum and hippocampus of mice by immunoblotting assay. The 6-OHDA animals showed a significant increase in the immobility time and rotations compared with the control group. Both physical exercises prevented the depressive-like behavior and the increase in the number of rotations induced by 6-OHDA. In addition, a significant decrease in pro-BDNF, BDNF, and TrkB levels were observed in the 6-OHDA-administered group. Physical exercise restored the levels of the pro-BDNF, BDNF and its receptor, TrkB in the striatum and the hippocampus of mice submitted to 6-OHDA administration.

Conclusions: Our results demonstrated that training models were effective in the neuroprotection in striatum and hippocampus in mice exposed to the experimental model of PD.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/physical-training-prevents-depressive-like-behavior-and-bdnf-decrease-in-an-animal-model-of-parkinsons-disease/