Category: Parkinsonism, Atypical: MSA
Objective: This study aimed to characterize the cognitive profiles of multiple system atrophy (MSA) and explore the possible mechanisms involved using 18F-fluorodeoxyglucose (FDG) Positron Emission Tomography (PET).
Background: Cognitive decline has been accepted as a clinical symptom in MSA. However, the detailed profiles and underlying mechanisms remain unclear.
Method: Herein, 47 MSA patients were assessed by comprehensive neuropsychological tests covering executive function, attention, memory, visuospatial function and language domains. The cognition statuses were classified to dementia (MSA-D), mild cognitive impairment (MSA-MCI) and normal cognition (MSA-NC). All subjects accepted 18F-FDG PET imaging. The cerebral metabolism differences among cognitive statuses and correlations between regional FDG uptake and cognitive lesions in 5 domains were analyzed using statistical parametric mapping.
Results: Cognitive impairments were observed in all the five domains, primarily in attention, memory and executive function. Twenty-one and twelve patients were classified as MSA-MCI and MSA-D. In 18F-FDG imaging, MSA-D patients exhibited hypometabolism in frontal lobe and hypermetabolism in temporal lobe compared with MSA-NC. Correlation analysis showed the executive function/ attention scores correlated positively with the metabolism in frontal gyrus, and negatively with that in lentiform nucleus, insula, cingulate and temporal lobe.
Conclusion: Cognitive impairments were not rare in MSA, and the hypometabolism in frontal lobe and hypermetabolism in temporal lobe contributed to such impairments.
To cite this abstract in AMA style:C. Shen, F.T Liu, JJ. Ge, P. Wu, C.T Zuo, J. Wang. Clinical profile and cerebral metabolic characteristic of cognitive impairments in multiple system atrophy [abstract]. Mov Disord. 2020; 35 (suppl 1). https://www.mdsabstracts.org/abstract/clinical-profile-and-cerebral-metabolic-characteristic-of-cognitive-impairments-in-multiple-system-atrophy/. Accessed December 5, 2023.
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MDS Abstracts - https://www.mdsabstracts.org/abstract/clinical-profile-and-cerebral-metabolic-characteristic-of-cognitive-impairments-in-multiple-system-atrophy/