Combining alpha-synuclein PET and seeded amplification assays to improve the diagnostic accuracy of Multiple System Atrophy of the Parkinsonian subtype (MSA-P)
Objective: To determine whether the combination of spatial (PET [18F]ACI-12589) and conformational (skin seed amplification assay; SAA) a-syn data aids the early differential diagnosis of…Pure Autonomic Failure As a Severe “Body-First Subtype” of Lewy Body Disease: A Multimodal Imaging Study of the Autonomic Nervous System
Objective: Using multi-modal imaging this study aimed to characterize the deterioration of the parasympathetic and sympathetic nervous system in pure autonomic failure (PAF) in comparison…Mapping Cholinergic Signaling in Parkinson Disease Using [18F]VAT
Objective: To determine how cholinergic signaling changes within Parkinson Disease (PD) and how these differences relate to the progression of cognitive and behavioral symptoms. Background:…Correlation of lmaging Markers with Clinical Features in Multiple System Atrophy Patients
Objective: This study aims to investigate the correlation between visually assessable imaging markers and their clinical symptoms in Multiple System Atrophy (MSA) patients. Background: MSA is…Neuroimaging Factors Differentially Associated with Pathology and Clinical Presentation
Objective: Examine utility of a factor analysis approach to neuroimaging data in Lewy body disease (LBD) and Alzheimer’s disease (AD). Background: Significant heterogeneity exists among patients…Cardiac Mitochondrial Complex I Integrity Predicts Axial Symptom Severity in Parkinson’s Disease
Objective: In the present work, we investigated whether cardiac mitochondrial dysfunction might also be associated with the severity of PIGD symptoms in PD patients. Background:…Optical Coherence Tomography Findings in Multiple System Atrophy: Insights into Disease Subtypes, Clinical Correlations, and Dopaminergic Degeneration
Objective: This study aimed to evaluate optical coherence tomography (OCT) findings in multiple system atrophy (MSA) patients, with a focus on disease subtypes, clinical correlations,…The dementia with Lewy bodies related metabolic brain pattern (DLBRP) – a multicentric validation
Objective: Dementia with Lewy bodies-related pattern (DLBRP) has been identified from the FDG PET brain imaging of DLB patients and healthy controls previously. A multicentric…Distinguishing Parkinson’s disease from atypical Parkinsonian syndrome using multistage deep learning based on dopamine transporter imaging
Objective: We made the diagnostic model using a deep learning algorithm based on dopamine transporterWe made the diagnostic model using a deep learning algorithm based…Longitudinal progress and clinical relevance of 18F-Florzolutau PET in patients with PSP: a one-year follow-up study
Objective: Here we aimed to explore the progress of 18F-Florzolotau PET and its clinical relevance in patients with PSP during one-year follow-up. Background: The 18F-Florzolotau…
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