MDS Abstracts

Abstracts from the International Congress of Parkinson’s and Movement Disorders.

MENU 
  • Home
  • Meetings Archive
    • 2024 International Congress
    • 2023 International Congress
    • 2022 International Congress
    • MDS Virtual Congress 2021
    • MDS Virtual Congress 2020
    • 2019 International Congress
    • 2018 International Congress
    • 2017 International Congress
    • 2016 International Congress
  • Keyword Index
  • Resources
  • Advanced Search

Dopaminergic and Metabolic Imaging in Parkinson’s Disease motor subtypes and their relations to parkinsonian tremor

J. Zhao, L. Li, P. Wu, J. Wang, C.T. Zuo (Shanghai, China)

Meeting: 2018 International Congress

Abstract Number: 1473

Keywords: Cerebellum, Positron emission tomography(PET), Resting tremors

Session Information

Date: Monday, October 8, 2018

Session Title: Parkinson's Disease: Neuroimaging And Neurophysiology

Session Time: 1:15pm-2:45pm

Location: Hall 3FG

Objective: The mechanism underlying rest tremor of Parkinson’s disease(PD), while likely differing from those underlying akinesia and rigidity, remains unclear. The objective of this study is to investigate neuroimage profiles of parkinsonism tremor and underling pathophysilogical features.

Background: Various neuroimaging modalities have been used to characterize the brain pathology underlying the motor and non-motor manifestations of PD. However, the results of previous dopaminergic PET/SPECT studies that investigated parkinsonian motor heterogeneity were quite inconclusive. Number and scale of previous FDG studies were limited. These finding require validation by other studies using larger samples and different imaging techniques.

Methods: Resting-state 18F-FDG PET imaging was performed in 136 patients with PD. Among them, 102 PD patients performed 11C-CFT PET imaging at the same time. Patients were divided into tremor dominant(TD) group and akinetic-rigid(AR) group. DAT bindings, PDRP expressions and maps of regional metabolism were compared between groups. UPDRS-III motor sub-scores were used to correlate with DAT bindings ,PDRP expressions and regional cerebral metabolic rate of glucose (rCMRglc).

Results: DAT bindings and PDRP expressions were not significantly different between motor subgroups. Hypermetabolism in bilateral cerebellum/dentate nucleues and contralateral primary sensory cortex was found in TD group compared to AR group, and hypometabolism in contralateral medial frontal gyrus, superior frontal gyrus and cingulate gyrus. For tremor severity, a positive correlation was found with rCMRglc of hypermetabolic regions.

Conclusions: These data showed that dopamine dysfunction is insufficient to explain parkinsonian tremor. Activation of cerebellum/dentate nucleues together with primary sensory cortex may engage in the cerebello-thalamo-cortical circuit, therefore contribute to PD tremor.

To cite this abstract in AMA style:

J. Zhao, L. Li, P. Wu, J. Wang, C.T. Zuo. Dopaminergic and Metabolic Imaging in Parkinson’s Disease motor subtypes and their relations to parkinsonian tremor [abstract]. Mov Disord. 2018; 33 (suppl 2). https://www.mdsabstracts.org/abstract/dopaminergic-and-metabolic-imaging-in-parkinsons-disease-motor-subtypes-and-their-relations-to-parkinsonian-tremor/. Accessed July 7, 2025.
  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print

« Back to 2018 International Congress

MDS Abstracts - https://www.mdsabstracts.org/abstract/dopaminergic-and-metabolic-imaging-in-parkinsons-disease-motor-subtypes-and-their-relations-to-parkinsonian-tremor/

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • Covid vaccine induced parkinsonism and cognitive dysfunction
  • What is the appropriate sleep position for Parkinson's disease patients with orthostatic hypotension in the morning?
  • Welcome to the MDS Abstracts Site
  • Life expectancy with and without Parkinson’s disease in the general population
  • Nilotinib for treating MSA: A preclinical proof of concept study
    • Welcome to the MDS Abstracts Site
    • Effect of marijuana on Essential Tremor: A case report
    • Advanced Search
    • Increased Risks of Botulinum Toxin Injection in Patients with Hypermobility Ehlers Danlos Syndrome: A Case Series
    • Covid vaccine induced parkinsonism and cognitive dysfunction
    • Help & Support
    • About Us
    • Cookies & Privacy
    • Wiley Job Network
    • Terms & Conditions
    • Advertisers & Agents
    Copyright © 2025 International Parkinson and Movement Disorder Society. All Rights Reserved.
    Wiley