Objective: To evaluate the effect of gait function activation on hypomimia in patients with Parkinson’s disease (PD).

Background: Hypomimia, a reduction in facial expressivity, is a common and socially disabling symptom in Parkinson’s disease (PD), contributing to communication difficulties and stigma. While gait disorders are a well-recognized motor feature of PD, the relationship between axial motor function and facial expression remains underexplored. Both hypomimia and gait impairment are manifestations of overall hypokinesia, suggesting a potential shared pathophysiological mechanism. However, it is unknown whether improving gait function may positively influence facial movements. This study aimed to investigate the effect of targeted gait activation on hypomimia in PD patients.

Method: The study included 18 patients with PD at Hoehn and Yahr stages 2-3, aged 70 [65; 76] years. Facial expression was assessed using a proprietary computer-based video analysis system for tracking facial muscle movements. Gait activation was performed using a specialized device designed for functional foot therapy, which mechanically stimulates push-off at the moment the foot lifts off the supporting surface.

Results: Activation of gait function led to statistically significant improvements in facial movements. Specifically, blink rate increased (p = 0.022), vertical eyebrow movement amplitude during frowning improved (p = 0.048), and horizontal mouth movement amplitude during reading increased (p = 0.012).

Conclusion: The observed reduction in hypomimia through modulation of overall hypokinesia provides a rationale for developing rehabilitation strategies that simultaneously address both gait and facial impairments in Parkinson’s disease.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/gait-activation-improves-hypomimia-in-parkinsons-disease/