MDS Abstracts

Abstracts from the International Congress of Parkinson’s and Movement Disorders.

MENU 
  • Home
  • Meetings Archive
    • 2024 International Congress
    • 2023 International Congress
    • 2022 International Congress
    • MDS Virtual Congress 2021
    • MDS Virtual Congress 2020
    • 2019 International Congress
    • 2018 International Congress
    • 2017 International Congress
    • 2016 International Congress
  • Keyword Index
  • Resources
  • Advanced Search

Indirect treatment comparison of valbenazine with deutetrabenazine for improvement in total maximal chorea score in Huntington disease

R. Mehanna, E. Furr Stimming, D. Haubenberger, O. Klepitskaya, S. Aggarwal, S. Kumar, O. Topaloglu, J. Goldstein, E. Kayson, M. Serbin (Houston, USA)

Meeting: 2023 International Congress

Abstract Number: 890

Keywords: Chorea (also see specific diagnoses, Huntingtons disease, etc): Treatment

Category: Huntington's Disease

Objective: To conduct an indirect treatment comparison (ITC) between valbenazine and deutetrabenazine using data from clinical trials in adults with chorea associated with Huntington disease (HD).

Background: Chorea is a hallmark motor symptom of HD. Tetrabenazine and deutetrabenazine are currently approved by the FDA for the treatment of chorea associated with HD. Valbenazine is currently under FDA review for that indication. There is no available comparison between the efficacy of deutetrabenazine and valbenazine in the treatment of chorea associated with HD.

Method: The outcome of interest of this indirect comparison based on clinical trial data was the mean change in total maximal chorea (TMC) score. For deutetrabenazine and placebo, the mean change and 95% confidence interval values were digitally extracted from the chart in the pivotal trial publication (First-HD [N=90]). For valbenazine and placebo, the values were obtained from the clinical study report (KINECTTM-HD [N=125]). The mean change for drug versus placebo was estimated using the inverse variance method. An ITC of valbenazine versus deutetrabenazine was conducted using the Bucher method at 2,4,6 weeks and at maintenance (average of weeks 9 and 12 for deutetrabenazine, and of weeks 10 and 12 for valbenazine).

Results: The ITC of the TMC score improvement significantly favored valbenazine over deutetrabenazine at 2 and 4 weeks. The relative treatment effects for valbenazine versus deutetrabenazine were -1.87 (95% CI: -3.23, -0.52; p<0.05) at 2 weeks, and -1.84 (95% CI: -3.43, -0.25; p<0.05) at 4 weeks. At 6 weeks and at maintenance, the difference of valbenazine versus deutetrabenazine demonstrated relative treatment effects of -0.84 (95% CI: -2.45, 0.78; p=NS) and -0.77 (95% CI: -2.42, 0.87; p=NS), respectively.

Conclusion: In this indirect comparison of valbenazine and deutetrabenazine, valbenazine improved chorea as early as week 2 (at the initial 40 mg dose) and had a therapeutic effect similar to deutetrabenazine during the maintenance phase. Subsequent analyses will include indirect comparisons of treatment effects on other endpoints, including safety outcomes.

To cite this abstract in AMA style:

R. Mehanna, E. Furr Stimming, D. Haubenberger, O. Klepitskaya, S. Aggarwal, S. Kumar, O. Topaloglu, J. Goldstein, E. Kayson, M. Serbin. Indirect treatment comparison of valbenazine with deutetrabenazine for improvement in total maximal chorea score in Huntington disease [abstract]. Mov Disord. 2023; 38 (suppl 1). https://www.mdsabstracts.org/abstract/indirect-treatment-comparison-of-valbenazine-with-deutetrabenazine-for-improvement-in-total-maximal-chorea-score-in-huntington-disease/. Accessed May 15, 2025.
  • Tweet
  • Email
  • Print

« Back to 2023 International Congress

MDS Abstracts - https://www.mdsabstracts.org/abstract/indirect-treatment-comparison-of-valbenazine-with-deutetrabenazine-for-improvement-in-total-maximal-chorea-score-in-huntington-disease/

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • Yerba Mate (Ilex paraguaiensis) protects dopaminergic neurons degeneration and improve their maturation in culture
  • #26133 (not found)
  • Effect of marijuana on Essential Tremor: A case report
  • Increased Risks of Botulinum Toxin Injection in Patients with Hypermobility Ehlers Danlos Syndrome: A Case Series
  • Covid vaccine induced parkinsonism and cognitive dysfunction
  • Estimation of the 2020 Global Population of Parkinson’s Disease (PD)
  • Patients with Essential Tremor Live Longer than their Relatives
  • Help & Support
  • About Us
  • Cookies & Privacy
  • Wiley Job Network
  • Terms & Conditions
  • Advertisers & Agents
Copyright © 2025 International Parkinson and Movement Disorder Society. All Rights Reserved.
Wiley