Session Information
Date: Sunday, October 7, 2018
Session Title: Phenomenology and Clinical Assessment Of Movement Disorders
Session Time: 1:45pm-3:15pm
Location: Hall 3FG
Objective: Evaluating the maintenance of safinamide 100 mg daily as a long-term treatment.
Background: The effects of safinamide were investigated in studies 016, 018 and SETTLE (clinical trials). Both studies 016 and SETTLE were 6 month, double blind, placebo-controlled trials comparing safinamide versus placebo as adjunct therapy to levodopa where 89% and 88% patients, respectively, maintained the treatment during these 6 months. Study 018 was an 18-month extension of 016 trial where 80% patients completed the study. This may suggest that safinamide 100 mg can be a long-term treatment that will delay medication adjustment in PD.
Methods: In this retrospective study reviewing the patients treated in our clinical practice with 100 mg safinamide as add-on to levodopa, we evaluate the time to an additional antiparkinsonian drug intervention.
Results: We have 70 patients with 100 mg safinamide daily with an average time of 12 months follow up. Among them, 87.14% (n=61) remain in treatment without any adjustment in levodopa or in other concomitant medications since the beginning of 100 mg safinamide treatment. Only 9 patients required a medication adjustment (12.86%, n=9) and the average time for additional antiparkinsonian drug intervention was 6 months. In 4 patients an ICOMT was added and in 5 patients we increased the dopamine agonist.
Conclusions: Safinamide 100 mg has shown long-term efficacy and safety in our clinical practice, being a PD medication that could delay an additional antiparkinsonian drug intervention.
To cite this abstract in AMA style:
N. Foncea. Maintenance of safinamide 100 mg daily long-term [abstract]. Mov Disord. 2018; 33 (suppl 2). https://www.mdsabstracts.org/abstract/maintenance-of-safinamide-100-mg-daily-long-term/. Accessed October 5, 2024.« Back to 2018 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/maintenance-of-safinamide-100-mg-daily-long-term/