Session Time: 1:45pm-3:15pm
Location: Agora 3 West, Level 3
Objective: The aim of the current study is to explore the synergistic effects of revasterol and Carpogon capitatus extract Roxb in rotenone induced rat model of Parkinson’s diseases via downregulation of oxidative stress and neurobehavioral characteristics.
Background: Parkinson’s diseases is the most common age related neurodegenerative disorder in which destruction of dopaminergic neurons and accumulation of α-synuclein protein in the substantia nigra pars compacta of the mid brain. Oxidative stress is the other factor which causes imbalance in metabolism of dopamine. Carpogon capitatus extract and Revasterol are effective biomolecule and has been used in Ayurvedic medicine to treat various dysfunctions.
Method: Swiss albino rats were subcutaneously injected with rotenone at a dose level of 1.5 mg/kg B.W. to produce symptoms of PD. Pre-treatment with revasterol and Carpogon capitatus extract to all the rats except normal group. Behaviour paradigms were monitored by hang and catalepsy test. Supernatant of brain were used to estimate the biochemical and neurochemical parameters. Pro-inflammatory cytokines i.e. tumor necrosis factor alpha and interleukin-1β were also evaluated.
Results: Finding suggested that after the administration of rotenone significantly induced neurobehavioual paradigms as well as produced oxidative dysfunction by increasing the lipid peroxidation. They also significantly downregulated the level of dopamine (DA) and 5-hydroxytryptamine (5-HT). Treatment with revasterol and Carpogon capitatus extract significantly amended the cognitive impairment by increased level of antioxidant parameter and decreased LPO and nitrite level in nigrostriatal tissue of rat brain. Moreover, significantly reduced the proinflammatory cytokines and enhanced level of DA and 5-HT when compared to rotenone induced group.
Conclusion: Finding proved that extract of Carpogon capitatus Roxb and revasterol restores the cognitive behaviour and used as a therapeutic agent in the management of Parkinson’s diseases.
To cite this abstract in AMA style:DS. Singh, MS. Singh, PK. Kumar, YK. Gupta. Neuromodulatory potentials of revasterol and Carpogon capitatus Roxb on the rat brain: Novel approach for Parkinson’s diseases [abstract]. Mov Disord. 2019; 34 (suppl 2). https://www.mdsabstracts.org/abstract/neuromodulatory-potentials-of-revasterol-and-carpogon-capitatus-roxb-on-the-rat-brain-novel-approach-for-parkinsons-diseases/. Accessed November 29, 2023.
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MDS Abstracts - https://www.mdsabstracts.org/abstract/neuromodulatory-potentials-of-revasterol-and-carpogon-capitatus-roxb-on-the-rat-brain-novel-approach-for-parkinsons-diseases/