Investigating the cellular role of LRRK2 in the immune system
Objective: The objective of this project is to investigate the effect of Leucine Rich-Repeat Kinase 2 (LRRK2) dysfunction in the signalling mechanisms in macrophages and…Ambulatory monitoring of electrodermal activity (EDA) and Heart Rate Variability (HRV) for prediction of motor fluctuations in Parkinson’s Disease (PD)
Objective: To determine whether changes in EDA and HRV are associated with motor fluctuations in patients with PD Background: EDA and HRV are affected in…Special features of parkinsonism with congenital anomalies of cerebral vessels
Objective: To study the features of the flow of parkinsonism with congenital anomalies of cerebral vessels. Background: Analysis of the study of neurological status, data…Parkinsonian syndrome associated to C9orf72 expansion
Objective: To describe a case of parkinsonian syndrome associated to C9Orf72 expansion followed by ALS development Background: C9Orf72 expansions are known to be the most…Glabellar tap predicts dopamine transporter deficiency in parkinsonism
Objective: The objective of this study was to investigate the association between glabellar tap findings with nigrostriatal dopamine function in patients with unclear parkinsonism. Background:…Multiple system atrophy with predominant striato-nigral degeneration (MSA-P) and TDP-43 pathology: an unusual pathologic variant of MSA
Objective: To report a patient with MSA with concomitant occurrence of TDP-43-labeled and a-synuclein labeled inclusions in oligodendrocytes. Background: The pathologic hallmark in multiple system atrophy…PARKINSON DISEASE HAMPERS PARTICIPATION IN THE CIVIC RESPONSIBILITY OF VOTING: a study of barriers to expression of a fundamental human right
Objective: To determine the impact of PD on the participation of persons with Parkinson disease in the recently concluded national elections in Lagos,Nigeria, and explore…Blood brain barrier dysfunction cause idiopathic adult onset ventriculomegaly?
Objective: Our hypothesis is BBB disruption causes idiopathic adult onset ventriculomegaly (IAOV) also, astrocyte specific mitochondrial dysfunction is associated with BBB damage. Background: The cause…Efficacy, Safety, and Tolerability of Supratherapeutic Doses of Apomorphine Sublingual Film for the Treatment of “OFF” Episodes in Patients With Parkinson’s Disease
Objective: To evaluate efficacy, safety, and tolerability of supratherapeutic doses of apomorphine sublingual film (APL-130277; APL) in patients with Parkinson’s disease (PD) and “OFF” episodes.…Pharmacokinetics of Accordion Pill™ Carbidopa/Levodopa Following Multiple Doses in Patients With Parkinson’s Disease
Objective: To perform a pharmacokinetic (PK) assessment of a novel carbidopa/levodopa drug delivery system (Accordion Pill™; AP-CD/LD) and to determine if multiple doses of AP-CD/LD…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.