Early Caudate Dopaminergic Loss as an Imaging Biomarker of Cognitive Impairment in Parkinson’s Disease: A Longitudinal Analysis
Objective: The primary objective was to determine whether early pre-synaptic caudate denervation, measured using 123 I ioflupane SPECT quantitative metrics, provides independent and incremental prognostic value…Micro- and Nanoplastics in Parkinson’s Disease Pathogenesis An Emerging Environmental Risk Factor
Objective: To synthesize current experimental and translational evidence supporting the hypothesis that micro- and nanoplastics (MNPs) may contribute to Parkinson’s disease (PD) pathogenesis through neuroinflammatory…Neurological Wilson’s disease: another form of tauopathies?
Objective: The authors would hope to identify distribution of Tau protein within the brain of Wilson's disease patients by tau-targeted positron emission tomography (PET) tracers Background:…The Relationship Between Substantia Nigra Hyperchogenicity and Clinical Features and Disease Progression in Parkinson’s Disease Patients
Objective: To investigate the relationship between substantia nigra hyperechogenicity (SN+) and clinical features and disease progression in patients with Parkinson's disease (PD) under transcranial sonography…Ulixacaltamide Demonstrates Superiority Over Placebo as Monotherapy and as Add-on to Propranolol in Essential Tremor: Phase 3 ESSENTIAL3 Study 1
Objective: To evaluate efficacy of ulixacaltamide, a selective T-type calcium channel modulator, versus placebo in adults with essential tremor (ET) as monotherapy and as add-on…Parkinson’s Disease Early Diagnostic and Prognostic Biomarkers Identified by Large-scale Plasma and Cerebrospinal Fluid Proteomic Profiling
Objective: To identify reliable diagnostic and prognostic protein biomarkers for early-stage Parkinson’s disease (PD) using large-scale proteomic profiling of plasma and cerebrospinal fluid (CSF).To identify…Strategies for Harmonising Clinical Data for Multi-Centre, Large Scale Genome-Wide Association Studies
Objective: To establish a data harmonisation framework for classifying cognitive status in Parkinson’s disease (PD) across multiple study and data types to facilitate large-scale genetic…Targeting c-Abl/Drp1-Dependent Mitochondrial Fission: Neuroprotective Effects of Berberine Chloride in Parkinson’s Disease Models
Objective: To investigate the neuroprotective potential of berberine chloride in Parkinson’s disease (PD) by modulating pathological mitochondrial fission through c-Abl–mediated Drp1 phosphorylation using integrated bioinformatics,…Assessing Agreement of Self-Perception of Dysphagia in Individuals with Parkinson Disease and their Caregivers
Objective: To investigate the association of self-perception of dysphagia in individuals with Parkinson disease (IwPD) with their caregivers’ perceptions at early, mid and late stages…Electrocardiographic Indicators of Autonomic Dysfunction in Parkinson’s Disease: A Scoping Review and Meta-analysis
Objective: To systematically map and quantitatively synthesize evidence on ECG-derived markers associated with autonomic dysfunction in PD and evaluate their ability to differentiate patients from…
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