Optimization of Synucleinopathy and Nigrostriatal Degeneration Induced by Injection of Alpha-Synuclein Preformed Fibrils into Rat Striatum
Objective: Optimization of the surgical parameters (intrastriatal placement and concentration of alpha-synuclein preformed fibrils; α-syn PFFs) to increase the magnitude of nigrostriatal α-syn pathology and…Genetic knock-down of HDAC4 attenuates rotenone-induced abnormal expression of α-synuclein by affecting autophagic flux in SH-SY5Y Cells
Objective: To assess whether histone deacetylase 4 (HDAC4) is related to the abnormal expression of α-synuclein (α-syn) via the autophagy pathway. Background: The overexpression and…Vitamin D in the Parkinson’s Associated Risk (PARS) Study
Objective: The purpose of this study was to evaluate vitamin D levels in a population at risk for developing Parkinson’s disease (PD). Background: Vitamin D…Evaluation of CSF cytokine profiles in people with Parkinson disease and age-matched controls.
Objective: To investigate the levels of cytokines in the cerebrospinal fluid of subjects with Parkinson disease (PD) and matched healthy controls. Background: Neuroinflammation is thought…Deep Brain Stimulation (DBS) battery longevity of Medtronic Activa SC is briefer than preceding Soletra models, a within subject analysis
Objective: To contrast the durations of Activa SCs with the durations of preceding Soletra neurostimulator models within the same individuals programmed at near constant parameters.…The comparison of urine microvesicle reflecting gut microbiome between Parkinson’s disease and healthy control
Objective: The objective of this study to compare urine microvesicle between Parkinson’s disease(PD) and healthy controls Background: Recent researches showed that gut microbiome interact with central…Insulin Resistance In Non-Diabetic People With Parkinson’s Disease
Objective: To study the incidence of insulin resistance (IR) in people with Parkinson's Disease (PD) and its relationship with motor and non-motor symptoms of the…Epitope mapping of CSF auto-antibodies to alpha-synuclein
Objective: To identify α-synuclein (α-syn) epitopes bound by endogenous auto-antibodies in CSF from healthy controls (HC) and Parkinson disease (PD) patients. Background: In PD, endogenous…Alpha-synuclein protein homeostasis and oligomerization in iron-overloaded cells expressing mutant HFE
Objective: Study the direct and indirect effects of iron overload on alpha synuclein homeostasis in a genetic model of hemochromatosis (HFE) Background: Parkinson’s disease (PD)…Freezing of gait in Parkinson’s disease consists of unique pressure-based gait phase transitions
Objective: To develop a method to detect freezing of gait in real time Background: Freezing of gait (FOG) is a major debilitating symptom and cause…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.