Somatosensory Mismatch Negativity is abnormal in Cervical Dystonia.
Objective: Here, we hypothesised that somatosensory abnormality in patients with dystonia relates to a more general deficit in pre-attentive error/deviant detection . Background: Dystonia is a common…Correlation Between Time Course, Level of Impact of Illness, Functionality, and Postural Measures of Patients with Cervical Dystonia.
Objective: To correlate the evolution over time, level of impact of illness, functionality and posture of head and trunk in the coronal plane of patients…Towards a reappraisal of Status Dystonicus : a cohort study
Objective: The objective of the study is to find the key factors driving dystonia patients at risk to develop SD. Background: Status Dystonicus (SD) is…History and Management of Status Dystonicus
Objective: To describe a consecutive series of 40 status dystonicus patients, identify major clinical characteristics and to document medical and surgical management. Background: Characteristics and evolution…Improvement Observed in Children with combined GPi and VL Thalamus Deep Brain Stimulation for the Treatment of Secondary Dystonia
Objective: To present 5 children with Gpi and VL thalamus Deep-Brain Stimulation for treatment of secondary dystonia. Background: The target for deep brain stimulation (DBS) in…Intermuscular and cortico-muscular coherence of patients with writer’s cramp
Objective: We present our pilot data on the Intermuscular coherence (IMC) and cortico-muscular coherence (CMC) pattern in writer’s cramp (WC) patients, healthy participants and patients…Clinical effects are persistent at the end of one abobotulinumtoxinA injection cycle in cervical dystonia – results from a meta-analysis of 1091 subjects
Objective: Evaluate the impact of one injection cycle of abobotulinumtoxinA (AboBoNT-A; Dysport®) on the clinical characteristics of cervical dystonia (CD). Background: The pharmacologic effects of…Brainstem connection of Writer’s cramp: Electrophysiological correlates
Objective: In this study, we explored the involvement of brainstem in Writer’s cramp (WC) patients through pre-pulse inhibition of blink reflex and Start-React paradigm. Background:…Non motor symptoms in patients with Writer’s cramp
Objective: We aim to explore the non-motor features of WC patients and correlate those with motor symptoms. Background: Writer’s cramp (WC) is essentially a motor…Multiple Neural Networks dysfunction in Primary Blepharospasm: An Independent Components Analysis Study
Objective: This study aimed to explore altered functional brain connectivity and the possible correlations of these networks with clinical variables in BPS. Background: Primary blepharospasm (BPS) is a focal dystonia characterized by involuntary blinking and eyelid spasms. The pathophysiology of BPS remains unclear. Methods: Twenty-five patients with BPS and 25 age-and gender-matched healthy controls received resting-state fMRI scan. Group ICA was performed with the GIFT toolbox. Results: (1) There were no significant differences in the demographic variables between two groups besides the HAMA scores [table 1]. (2) Comparing with healthy control group, BPS patients exhibited different resting-state connections within sensory-motor network (SMN), right frontoparietal network (rFPN) and salience network (SN) [figure 1, figure 2]. BPS patients exhibited decreased connectivity within SMN that involved regions of the bilateral primary sensorimotor cortex, supplementary motor area, right superior frontal gyrus (BA 6), bilateral precuneus and left superior parietal cortex [table 2]. Within rFPN, decreased connections were observed in the middle frontal gyrus, DLPFC and inferior frontal gyrus [table 3]. Regarding salience network, increased connectivity was observed in the left superior frontal gyrus and middle frontal gyrus (including the DLPFC) [table 4]. We found positive correlation between the left superior frontal gyrus and HAMA scores, but this result was not significant. (3) Among the BPS patients, 12 performed sensory tricks positive (ST+), 9 perform sensory tricks negative (ST-). ST+ as compared to ST- patients exhibited significant higher connectivity in right premotor cortex within SMN [figure 3, table 5]. The results also showed a significant negative correlation between the right superior frontal gyrus and disease duration (Pearson's correlation r = -0.414, p = 0.038)[figure 4]. (4) We compared the SMN connectivity maps from pre- and after- treatment of 6 patients, but found no significant result. Conclusions: Multiple neural networks dysfunction may play roles in BPS.
Abstracts from the International Congress of Parkinson’s and Movement Disorders.