Parkinson’s Progression Markers Initiative (PPMI): A Biomarker Engine for Therapeutic Development for PD and Related Synucleinopathies
Objective: PPMI is a longitudinal, observational study investigating clinical, imaging, genetic and biofluid biomarkers to accelerate therapeutic development for Parkinson’s disease (PD) and related synucleinopathies…A Randomized Clinical Trial of Immersive Virtual Reality and Cognitive Rehabilitation for Mild Cognitive Impairment in Parkinson’s Disease
Objective: To investigate the efficacy of Immersive Virtual Reality (IVR) and Computerized Cognitive Training (CCT) for mild cognitive impairment in Parkinson’s disease (PD-MCI) Background: PD-MCI…Oculomotor Abnormalities in Spinocerebellar Ataxia Type-12: A Functional Neuroimaging Study
Objective: This study aimed to investigate eye movements, specifically dysmetric saccades and cerebellar nystagmus, in Spinocerebellar Ataxia Type-12 (SCA12) using functional magnetic resonance imaging (fMRI)…Decreased Disease Burden in Motor-Related HD-HI Domains Among Adults With Huntington’s Disease Treated With Valbenazine
Objective: To evaluate the effects of valbenazine (VBZ) on mobility, abnormal movements, and hand/arm function as assessed using the Huntington’s Disease Health Index (HD-HI). Background:…Effect of Exenatide on disease progression in early Parkinson’s disease–a randomized, placebo controlled, single-center trial in Sweden
Objective: To identify biological mechanisms that mediate Exenatide's effect in the brain of patients with early Parkinson’s disease(PD). Background: Tracking PD progression remains a major challenge due to…Audit Of A Multidisciplinary Day Hospital For Parkinson’s and Falls (2019–2024)
Objective: To assess a multidisciplinary hospital day service for Parkinson’s disease and fall-related concerns, identify service gaps, and evaluate its 5-year impact. Background: The Day…Hypothalamic Atrophy in CANVAS/RFC1
Objective: We aimed to investigate hypothalamic volumetry in CANVAS/RFC1. Background: Cerebellar ataxia, neuropathy, and vestibular areflexia syndrome (CANVAS) is now recognized as a late-onset multisystem…Prospective observational study on the effects of physical exercise and lifestyle modifications in patients with Parkinson’s disease
Objective: This study aimed to assess the effectiveness of physical activity, which includes all movements that increase energy expenditure, in conjunction with exercise, characterized as…Are All Postural Reflexes Facilitated by Instability
Objective: To investigate whether postural reflexes evoked by both vestibular and axial stimuli are enhanced by instability. Background: Instability has been reported to increase vestibular-evoked…Widespread White Matter Changes in Manifest Huntington’s Disease
Objective: To characterize white matter changes in Huntington’s Disease (HD). Background: HD is a genetic neurodegenerative disorder characterized by motor, cognitive, and psychiatric symptoms. Diffusion Tensor…
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