Incidental Lewy Body disease and idiopathic Parkinson’s disease: from common pathogenic factors to the overlapping clinical features
Objective: To compare established early symptoms and risk factors associated with Parkinson’s disease (PD) in a cohort of incidental Lewy Body disease (iLBD) and healthy…Effects of Once-Daily Opicapone 50 mg on COMT activity: A Pooled Post-hoc Analysis of Two Phase 1 Studies
Objective: To assess the effects of opicapone (OPC) 50 mg adjunct to carbidopa/levodopa (CD/LD) on catechol-O-methyltransferase (COMT) activity by participants’ baseline characteristics using pooled data…A Phase 2 Clinical Trial Evaluating the Efficacy, Safety, Tolerability, and Pharmacokinetics of PRAX-944 in Adults with Essential Tremor
Objective: We present preliminary findings from PRAX-944-221, a Phase 2a clinical trial evaluating efficacy, safety, tolerability, and pharmacokinetics of PRAX-944 in adults with essential tremor…Functional movement disorder with mixed phenotype in a child with Asperger’s syndrome
Objective: To report a case of functional movement disorders (FMD) in a child with Asperger syndrome (AS). Background: FMD can be found in adults[1] and…Baseline Characteristics and Treatment Patterns of a Global Huntington Disease Population Stratified by Chorea Severity
Objective: To describe baseline characteristics and treatment patterns in patients with chorea associated with Huntington disease (HD) by severity of chorea. Background: Though multiple treatment…Efficacy of levodopa/benserazide dispersible tablet on delayed ON in Parkinson’s disease patients with motor fluctuations: a multicenter randomized open-label cross-over trial
Objective: This study aimed to assess the efficacy of levodopa/benserazide dispersible tablet on delayed ON in Parkinson’s disease (PD) patients with motor fluctuation. Background: Delayed…Diagnostic accuracy of dopamine SPECT in degenerative parkinsonism compared to neuropathological diagnosis.
Objective: To evaluate diagnostic accuracy of dopamine SPECT against neuropathological diagnosis in a large cohort of patients with parkinsonism. Background: Diagnosis of parkinsonian syndromes remains…Feasibility of telephonic voice samples to remotely monitor people with Parkinson’s disease residing in medically underserved rural regions
Objective: To explore the feasibility of collecting voice samples using digital voicemail in People with Parkinson’s disease (PwPD). Background: For many PwPD, the increased adoption…Perturbation-based balance training in individuals with Parkinson’s disease and freezing of gait
Objective: In the current study, we assessed the effect of a multisession training program based on unpredictable AP and ML perturbations of body balance on…Utilising multiple murine models to investigate sleep and circadian system dysfunction in PD
Objective: We aimed to investigate the impact of alpha-synuclein aggregation and spreading, and nigrostriatal dopaminergic degeneration on sleep homeostasis and circadian function. Background: Sleep dysfunction…
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