A phase IV, randomized, double-blind cross-over study comparing the clinical safety, efficacy and duration of abobotulinumtoxinA with onabotulinumtoxinA in adults with upper-limb spasticity: The DIRECTION study
Objective: To evaluate the safety and efficacy of abobotulinumtoxinA in comparison to onabotulinumtoxinA when used at optimized doses in approved muscles common to both products’…Effects of Gandouling Tablets on the Muscle tone and stiffness of patients with Wilson’s disease: a randomized, double-blind, placebo-controlled study
Objective: To analyze the effects of Gandouling tablets(GDL) on the tone and stiffness of the biceps brachii muscle in Wilson’s disease (WD) patients, and the correlation between…Improvement of spasticity-related pain with incobotulinumtoxinA treatment in children/adolescents with cerebral palsy: pooled analysis of Phase 3 studies
Objective: To assess the effect of incobotulinumtoxinA on spasticity-related pain (SRP) using pooled data from three large Phase 3 pediatric studies. Background: In children/adolescents with…The Cognitive Features of Idiopathic Cervical Dystonia: a cross-sectional study
Objective: To investigate the cognitive performance and the neuropsychiatric profile of patients with idiopathic adult-onset cervical dystonia (CD), to determine the occurrence of neuropsychiatric abnormalities…Cognitive-affective syndrome related to cerebellar hypometabolism secondary to Covid-19 infection : a case report
Objective: To describe a novel case of Covid-19-related cognitive affective syndrome with cerebellar hypometabolism and associated neuropathy. Background: Several Covid-19-related neurological diseases have been described, including…Differentiation of Mild Cognitive Impairment (MCI) progression to Alzheimer Disease (AD) vs Dementia with Lewy Bodies (DLB): Is this possible neuropsychologically?
Objective: Aim of the present review study was to describe and compare the neurocognitive features of MCI which could predict its progression to DLB vs…Carboplatin, Paclitaxel, and Nivolumab-induced Parkinsonism Responsive to Levodopa
Objective: To present the first reported case of reversible, levodopa sensitive, chemotherapy- induced parkinsonism due to the combination of carboplatin, paclitaxel, and nivolumab. Background: Many case reports describe antineoplastic agents causing reversible parkinsonism, most commonly, cyclophosphamide, cytosine arabinoside, and cyclosporine. To our knowledge, drug-induced parkinsonism related to combination therapy of paclitaxel, carboplatin, and nivolumab has never been…Risk of Tardive Dyskinesia in Patients with Tic Disorders: Preliminary Results
Objective: To determine the relative risk of tardive dyskinesia in patients with tic disorders by comparing three clinical populations: i) patients with tic disorders without…Reanalysis of a Patient-Reported Outcome (Tardive Dyskinesia Impact Scale) Shows Positive Results
Objective: To reanalyze the Tardive Dyskinesia Impact Scale (TDIS) and assess its potential utility in future TD studies. Background: TD is a persistent and potentially…Benefits of Treatment with OnabotulinumtoxinA in Naive and Non-naive Patients with Cervical Dystonia are Sustained over Time: Preliminary Completer Analysis from CD PROBE
Objective: This analysis evaluated the sustained effects of onabotulinumtoxinA in patients with CD who were naive or non-naive to botulinum toxin at enrollment in CD…
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