Efficacy of Incobotulinumtoxin/A Treatment for Children/Adolescents with Sialorrhea associated with Neurological Disorders
Objective: The SIPEXI (Sialorrhea Pediatric Xeomin Investigation) study investigated efficacy and safety of intraglandular incobotulinumtoxinA (incoBoNT/A) injections in children/adolescents with sialorrhea associated with neurological disorders…A cell-penetrating peptide (CPP) did not decrease 150-kDa BoNT/A toxin adsorption to surfaces or increase toxin potency or duration in a prototype formulation
Objective: To examine the effect of a cell-penetrating peptide (CPP) in a prototype formulation using toxin adsorption, in vivo potency, and duration analyses. Background: Unit…Tinospora Cordifolia protects against Rotenone induced degeneration of dopaminergic neurons in mouse model of Parkinson’s disease
Objective: To explore the neuroprotective mechanisms of T. cordifolia ethanolic extract against Rotenone (ROT)-intoxicated mouse model through proteomics approach. Background: The death of dopaminergic (DAergic)…Unravelling Voice Tremor In Movement Disorders: A Machine Learning Study
Objective: The aim of this study is to achieve a direct and objective discrimination between voice samples recoded from patients with essential tremor and dysphonia…Electrophysiological testing aids the diagnosis of tremor versus myoclonus in clinically challenging patients
Objective: We investigated how clinical electrophysiological testing can help to distinguish tremor versus myoclonus. Background: Tremor is the most common movement disorder and myoclonus its…Pallidal recordings in fully implanted dystonic patients: preliminary results
Objective: To describe oscillatory patterns of pallidal local field potentials (LFP) in fully implanted patients with dystonia. Background: New implantable devices for deep brain stimulation…Closing the Loop on Essential Tremor Using Thalamic and Cortical Control Signals
Objective: In this study, we show feasibility of a novel embedded closed-loop DBS (CL-DBS) that uses local field potential (LFP) oscillations of the alpha/beta band…Spinal Excitability and Plasticity in Hereditary Spastic Paraparesis: A Neurophysiological Study
Objective: To investigate spinal excitability and plasticity in patients with pure hereditary spastic paraparesis (HSP). Background: Pure HSP (SPG4) is a neurodegenerative disorder characterized by…A Case of Autoimmune Orofacial Dyskinesia associated with Striational Antibody
Objective: This is a case of steroid-responsive, autoimmune orofacial dyskinesia associated with extremely elevated striational [striated muscle] antibody. We present this instructive case to add…Botulinum toxin injections for sialorrhea in Parkinson´s disease and parkinsonism: 5 years follow up
Objective: Investigate the safety and efficacy of botulinum toxin type A in Parkinson´s disease and parkinsonism patients affected by sialorrhea Background: Sialorrhea is excessive salivation…
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