Validation of the Neuroprotective Potential of SLP-2 against alpha-synuclein neuropathology in a Mouse Model of Parkinson’s Disease
Objective: We aim to validate the neuroprotective potential of SLP-2 against α-syn neuropathology and neurodegeneration of dopaminergic neurons in a mouse model of Parkinson’s disease.…Safinamide Improves Sleep and Daytime Sleepiness in Parkinson´s Disease. Results from the SAFINONMOTOR Study
Objective: Our aim was to analyze the effectiveness of safinamide on sleep in Parkinson´s disease (PD) patients from the SAFINONMOTOR (an open-label study of the…Effect of oxytocin on response inhibition in Parkinson´s disease: a pilot study
Objective: To observe the effect of oxytocin (OXT) on response inhibition in Parkinson´s disease (PD) patients using dedicated saccadic tasks. Background: Cumulating evidence has shown…Early versus later levodopa and onset of motor fluctuations in PD: Observations from the Parkinson’s Outcomes Project
Objective: To characterize patients with early versus later levodopa exposure, defining “early” as within 2 years of Parkinson’s disease (PD) diagnosis, and to determine whether…The early post-transplant period in Parkinson’s disease: the low intravenous dose effect.
Objective: To compare the early results of the introduction of MSCs via different routs of administration on the dynamics of the motor symptoms in patients…Safety, tolerability and CNS effects after single and multiple doses of β-agonists in healthy volunteers and patients with Parkinson’s disease
Objective: This study aimed to assess the effects of β-agonists on central nervous system (CNS) functioning in healthy volunteers and patients with Parkinson’s disease. Background:…Gut bacterial tyrosine decarboxylase as a predictive biomarker to identify Parkinson’s disease patients with motor fluctuations requiring frequent levodopa administration
Objective: To Investigate the clinical relevance of tyrosine decarboxylating (TDC)-bacteria in patients with Parkinson’s Disease (PD). Background: Recently, we have shown that TDC-gut bacteria that…ABBV-0805, a novel α-synuclein oligomer selective antibody, prolonged lifespan and prevented accumulation of α-synuclein pathology in mouse models of Parkinson’s disease
Objective: We report on the pharmacological characteristics of ABBV-0805 (BAN0805), a monoclonal antibody that exhibits a high selectivity for human α-synuclein oligomers and very low…Classification of Advanced Parkinson’s Disease in OBSERVE-PD Patients Based on the MANAGE-PD Screening Tool
Objective: This post-hoc analysis evaluated uncontrolled patients from OBSERVE-PD identified as advanced Parkinson’s disease (APD) based on domains evaluated in section 2 of the MANAGE-PD…Apomorphine infusion before subthalamic deep brain stimulation. A prospective comparative study in the same 20 patients.
Objective: The objetive of this study was to compare the benefit of APO and STN-DBS in aPD in terms of motor (off daily hours, UPDRS…
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