Session Information
Date: Monday, September 23, 2019
Session Title: Genetics
Session Time: 1:45pm-3:15pm
Location: Les Muses Terrace, Level 3
Objective: To assess the genetic risk factors for Parkinson’s disease (PD) in a large population of patients with inflammatory bowel disease (IBD), as compared to non-IBD controls.
Background: Recent population-based studies have shown an increased risk of neurodegeneration in IBD patients as compared to the general population, suggesting a link between IBD and diseases like PD (1).
Method: We calculated a PD polygenic risk score (PRS) for each individual in the Material and Information Resources for Inflammatory and Digestive Diseases (MIRIAD) research database, which includes subjects diagnosed with Crohn disease (CD) and Ulcerative Colitis (UC). Genotypes from 2931 IBD patients and 218 non-IBD controls were included in the analysis. PD PRS was calculated as a weighted sum of the number of risk alleles carried by each individual (0, 1, or 2) at 41 known PD genetic risk loci, with weights proportional to the effect estimates from previously published large-scale association studies (2). R package Mangrove was utilized in the PRS calculation.
Results: PD PRS in IBD patients as a whole were not statistically different as compared to non-IBD controls (p=0.064). However, when analyzing the two distinct subgroups of IBD, we found that CD patients (n=1922) had a higher PD PRS compared to controls (p=0.01), while PD PRS in UC patients (n=714) could not be distinguished from controls (p=0.7). CD patients had significantly higher PD PRS compared to UC (p=0.0006). In addition, PD PRS was associated with a younger age at onset of CD (Beta=- 0.63, p=0.01).
Conclusion: Patients with CD have higher PD PRS compared to non-IBD controls, supporting previous epidemiological studies that show increased prevalence of PD in this cohort. UC patients in our study had a genetic risk for PD similar to non-IBD controls.
References: 1. Zhu F, Li C, Gong J, Zhu W, Gu L, Li N. The risk of Parkinson’s disease in inflammatory bowel disease: A systematic review and meta-analysis. Dig Liver Dis. 2019;51(1):38-42. doi:10.1016/j.dld.2018.09.017 2. Chang D, Nalls MA, Hallgrímsdóttir IB, et al. A meta-analysis of genome-wide association studies identifies 17 new Parkinson’s disease risk loci. Nat Genet. 2017. doi:10.1038/ng.3955
To cite this abstract in AMA style:
H. Maghzi, D. Li, E. Hogg, A. Garland-Becerra, E. Tan, A. Maghzi, D. Mcgovern, M. Tagliati. Parkinson’s disease Polygenic Risk Factor Scores in Patients with Inflammatory Bowel Disease [abstract]. Mov Disord. 2019; 34 (suppl 2). https://www.mdsabstracts.org/abstract/parkinsons-disease-polygenic-risk-factor-scores-in-patients-with-inflammatory-bowel-disease/. Accessed May 17, 2025.« Back to 2019 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/parkinsons-disease-polygenic-risk-factor-scores-in-patients-with-inflammatory-bowel-disease/