Category: Parkinson's Disease: Non-Motor Symptoms
Objective:
To outline the protocol for an upcoming study aimed at describing the non-motor symptoms (NMS) in Parkinson’s disease (PD) patients with heterozygous glucocerebrosidase (GBA) mutations (PD-GBA+) and their progression over 2 years.
Background: GBA mutations are the primary risk factor for PD. Patients with PD-GBA+ typically experience an earlier onset of symptoms and a higher prevalence of both motor and NMS, including significant cognitive impairment. Despite this, existing studies on the subject are limited, often cross-sectional or with brief follow-up durations.
Method: This study is a prospective, case-control study comparing PD-GBA+ patients (cases) to PD patients without mutations in a 64-gene panel related to PD (controls). Participants will be monitored over a 2-year period with comprehensive motor and non motor evaluations every six months.
Results: The findings will encompass a quantitative and qualitative profile of motor and NMS, including posturography and computerized tests for reaction speed, comparing symptom evolution between PD-GBA+ and PD-GBA- groups.
Conclusion: PD-GBA+ patients are hypothesized to exhibit earlier onset and more severe NMS. Our study seeks to verify this hypothesis through rigorous statistical analysis, contributing to the existing knowledge base.
To cite this abstract in AMA style:
I. Muro, L. López-Manzanares, P. Lorenzo, E. Casas, B. González, J. Masabanda, A. Arroyo, A. Hurtado, JP. Romero. Prospective and Controlled Glucocerebrosidase-related Parkinson’s Disease Evaluation of Non-Motor Symptoms (PROGENS-PD) [abstract]. Mov Disord. 2024; 39 (suppl 1). https://www.mdsabstracts.org/abstract/prospective-and-controlled-glucocerebrosidase-related-parkinsons-disease-evaluation-of-non-motor-symptoms-progens-pd/. Accessed October 10, 2024.« Back to 2024 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/prospective-and-controlled-glucocerebrosidase-related-parkinsons-disease-evaluation-of-non-motor-symptoms-progens-pd/