Session Time: 1:45pm-3:15pm
Location: Hall 3FG
Objective: Bacopa monnieri is largely treasured as a revitalizing herb used by Ayurvedic medical practitioners for almost 3000 years. The herb has been mentioned in several Ayurvedic treatises including Charaka Samhita and Sushruta Samhita in the 3rd century AD. Bacopa monnieri may improve circulation to the brain and even protect brain cell hence could be used as a potent agent against development of PD.
Background: Parkinson’s Disease (PD), is the contemporary name for a degenerative brain disease that has been recorded by humans. In ancient India, the practitioners of the medical system Ayurveda called it Kampavada. Bacopa monnieri is used in India since ancient times is also a day to day use herb.
Methods: A total of 50 adult male Wistar rats (NGBU, Laboratory Animal Center), weighting 200 g, were used. All model rats received 6-OHDA injection (6-OHDA injection: 6-OHDA, vitamin C powder, 0.3% 6-OHDA injection according to the ratio of 2.5:1 with saline. The injection was used when preparation and stored sealed, low temperature, and dark) stereotactic brain injection. After 6-OHDA administration 1d, 7d and 14d, 10 rats per group were observed every time. When the symptoms of PD progressed, we applied Bacopa monnieri seed powder extract in water to rodent models of Parkinson’s.
Results: Bacopa monnieri extract exhibits interesting antioxidant properties, expressed by its capacity to scavenge superoxide anion and hydroxyl radical, and to reduce H2O2 induced cytotoxicity and DNA damage in human fibroblast cells. Results showed promise in conquering the disease and protecting the brain from damage by the antioxidant activity of the extract in the hippocampus, frontal cortex and striatum.
Conclusions: Bacopa monnieri helps in coping with combined hypoxic, hypothermic and immobilization stress that could lead to the onslaught of ‘free radicals’ during the progress of PD.
To cite this abstract in AMA style:S. Sinha, P. Kumar. Putative treatment of Parkinson’s Disease using extract of Bacopa monnieri [abstract]. Mov Disord. 2018; 33 (suppl 2). https://www.mdsabstracts.org/abstract/putative-treatment-of-parkinsons-disease-using-extract-of-bacopa-monnieri/. Accessed December 1, 2023.
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MDS Abstracts - https://www.mdsabstracts.org/abstract/putative-treatment-of-parkinsons-disease-using-extract-of-bacopa-monnieri/