Category: Huntington's Disease
Objective:
This study aimed to investigate the shifting trends (2019-2024) in research on Huntington’s disease (HD)based on bibliometric lens.
Background:
Huntington’s disease is a movement disorder, a progressive neurodegenerative disease that is autosomal dominant causing gene mutations on human chromosome 4p16.3. The triad typical symptoms of HD are involuntary movements, psychiatric symptoms and progressive decline in cognitive function. This disease cannot be cured and current therapeutic modalities are limited to symptomatic therapies. Therefore various studies have been done on this disease.
Method:
This research employed the Scopus database from 2019 to 2024 for data collection. The inclusion criteria were original article written in English. The exclusion criteria were non original articles such as conference papers, editorials, letters, commentaries, and book chapters and studies not specifically related to HD. Co-occurrence analysis, co-authorship analysis, and visualization were done using VOSviewer software version 1.6.19.
Results:
The data used in this research was the international publication from the Scopus database. There were 791 scientific papers from 2019 to 2024 that discussed huntington disease. There were shifting trends of HD research from year to year. Several years ago, investigations on HD were mainly focused polyglutamine, CAG repeat, and age-of-onset of HD. Nowadays, many reseachers focused on gene expression, mutant huntingtin, autophagy, and its biomarkers. These topics drove the progression of HD research worldwide. Based on geographical study, the most prolific countries carrying out the research were Unites State, United Kingdom, China, Germany, and Italia. Interestingly, an absence of Africa’s contributions in HD was highlighted.
Conclusion:
This bibliometric analysis highlights the increasing attention and research focus on HD. The findings in our study may provide researchers useful information about new insight in future direction of huntington’s disease innovation. In addition, biomarker and diagnostic approach may be a promising approach to be used in the future to develop strategies to deal with huntington’s disease.
To cite this abstract in AMA style:
RN. Surbakti, RK. Praja. Shifting Paradigms In Huntington’s Disease Research: A Five-Year Scopus-Based Bibliometric Exploration [abstract]. Mov Disord. 2024; 39 (suppl 1). https://www.mdsabstracts.org/abstract/shifting-paradigms-in-huntingtons-disease-research-a-five-year-scopus-based-bibliometric-exploration/. Accessed October 5, 2024.« Back to 2024 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/shifting-paradigms-in-huntingtons-disease-research-a-five-year-scopus-based-bibliometric-exploration/