Category: Surgical Therapy: Parkinson's Disease
Objective: To determine whether the optimal electrode contact selected in Abbott deep brain stimulation (DBS) leads is the same using conventional versus image-guided programming (LEAD-DBS software).
Background: DBS programming is a subjective, time-consuming process that has increased in complexity with directional leads. Image guided programming is one tool that may help clinicians narrow the number of programing choices. It is not currently available with Abbott Infinity DBS devices, however, LEAD-DBS, an open access, patient specific DBS lead imaging localization software can be used in conjunction with the Abbott DBS devices to identify lead and electrode location.
Method: The patient-specific DBS lead and anatomy was modeled using the BrainLAB USA software. The pre-operative T1 and T2 MRI brain and post-operative CT brain images were exported. An algorithm automatically aligns (co-registers) and normalizes the images in a standard stereotactic space and reconstructs the lead/electrode(s). The software then displays the relative spatial position of the electrode in the target nucleus and surrounding structures.
All patients implanted from February 2023 to August 2024 with the Abbott Infinity DBS device will be included in this study. A clinician blinded to the patient’s active programming parameters will identify the optimal electrode ring using the LEAD-DBS images. A Pearson correlation coefficient will be used to measure the correlation between the optimal electrode on LEAD-DBS and patient’s active montage from a conventional mono-polar survey.
Results: Thus far, 11 patients (9 PD, 2 ET) have been identified (15 STN and 2 VIM leads). There was a high correlation (r(15)=.99; p<0.001) between the optimal electrode chosen from the LEAD-DBS image and what was programmed clinically.
Conclusion: These findings support using LEAD-DBS as a programming tool for clinicians using the Abbott Infinity system. Fourteen additional Abbott leads are scheduled to be implanted and programmed by August 2024. Final analysis will be presented.
To cite this abstract in AMA style:
J. Karl, S. Dong, C. Taylor, N. Shetty, J. Rosenow, M. Nolt, L. Verhagen Metman. Using LEAD-DBS to Identify the Optimal DBS Electrode in the Abbott Infinity System [abstract]. Mov Disord. 2024; 39 (suppl 1). https://www.mdsabstracts.org/abstract/using-lead-dbs-to-identify-the-optimal-dbs-electrode-in-the-abbott-infinity-system/. Accessed May 21, 2025.« Back to 2024 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/using-lead-dbs-to-identify-the-optimal-dbs-electrode-in-the-abbott-infinity-system/